老化ゲノムバイオマーカー研究チーム　

　研究テーマ：

分子老化バイオマーカー

1.

 Nakai, D., Shimizu, T., Nojiri, H., Uchiyama, S., Koike, H., Takahashi, M., Hirokawa, K., Shirasawa, T. : Coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q. Aging Cell. 3(5), 273-281, 2004.

2.

 Morimoto, A., Irie, K., Murakami, K., Masuda, Y., Ohigashi, H., Nagao, M., Fukuda, H., Shimizu, T., Shirasawa, T. : Analysis of the Secondary Structure of -Amyloid (A 42) Fibrils by Systematic Proline Replacement. J.Biol.Chem. 279(50), 52781-52788, 2004.

3.

 Huang, F., Shimizu, T., Ishihara, A., Yuasa, S., Nishimura, K., Kugiyama, T., Shirasawa, T. : Tissue hyperoxygenation promotes oxidative metabolism in motor unit. J.Neurosci.Res.80(4),584-591( 2005)

4.

 Baba, T., Shimizu, T., Suzuki, Y., Ogawara, M., Isono, K., Koseki, H., Kurosawa, H., Shirasawa, T. : Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice. J.Biol.Chem. 280(16),16417-16426(2005)

5.

 Uchiyama, S., Koike, H., Shimizu, T., and Shirasawa, T. A superoxide disumutase/catalase mimetic extends the lifespan of short-lived mev-1 mutant but not the wild type strain in Caenorhabditis elegans. Anti-Aging Med Res, 2(1), 39-47 (2005)

6.

 Irie, K., Murakami, K., Masuda, Y., Morimoto, A., Ohigashi, H., Ohashi, R., Takegoshi, K., Nagao, M., Shimizu, T., and Shirasawa, T. Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease. J Biosci Bioeng, 99(5), 437-447 (2005).

7.

 Huang, F., Nojiri, H., Shimizu, T., and Shirasawa, T. Beneficial effect of transfusion with low-affinity red blood cells in endotoxemia. Transfusion, 45(11), 1785-1790 (2005).

8.

 Masuda, Y., Irie, K., Murakami, K., Ohigashi, H., Ohashi, R., Takegoshi, K., Shimizu, T., and Shirasawa, T. Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR. Bioorg Med Chem, 13(24), 6803-6809 (2005).

9.

 Murakami, K., Irie, K., Ohigashi, H., Hara, H., Nagao, M., Shimizu, T., and Shirasawa, T. Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease. J Am Chem Soc, 127(43), 15168-15174 (2005).