財団法人東京都高齢者研究・福祉振興財団 東京都老人総合研究所
 トップページ > 研究紹介 > 老化ゲノムバイオマーカー研究チーム > 老化プロテオーム > 主要文献

老化ゲノムバイオマーカー研究チーム 

 研究テーマ:

老化プロテオーム

主要文献

1.

Toda, T., Kaji, K. and Kimura, N. : TMIG-2DPAGE : A new concept of two-dimensional gel protein database for research on aging. Electrophoreisis, 19(2), 344-348, 1998

2.

Toda, T., Satoh, M., Sugimoto, M., Goto, M., Furuichi, Y. and Kimura, N. : A comparative analysis of the proteins between the fibroblasts from Werner's syndrome patients and age-matched normal individuals using two-dimensional gel electrophoresis.Mech. Ageing Dev., 100(2), 133-143, 1998

3.

Toda, T.: Two-dimensional electrophoresis database. In Encyclopedia of Separation Science (Wilson, I. D., Adlard, T. R., Cooke, M., and Colin F. Poole, C. F., eds.) pp.2823-2832, Academic Press, New York, 2000

4.

Toda, T., Sugimoto, M., Omori, A., Matsuzaki, T., Furuichi, Y. and Kimura, N.: Proteomic analysis of Epstein-Barr virus-transformed human B-lymphoblastoid cell lines before and after immortalization. Electrophoresis, 21(9), 1814-1822, 2000

5.

Toda, T.: Current status and perspectives of proteomics in aging research. Exp. Gerontol., 35(6-7), 803-810, 2000

6.

Toda, T.: Proteome and Proteomics for the research on protein alterations in aging. New York Acad. Sci., 928, 71-78, 2001

7.

Nishigaki, R., Shinohara T., Toda, T., Omori, A., Ichinose, S., Itoh, M., Shirayoshi, Y.,Kurimasa, A., and Oshimura, M.: An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. Biochem. Biophys. Res. Comm. 295(1), 112-118, 2002

8.

Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H, Watanabe T, Ohama E, Tahimic CG, Kurimasa A, Oshimura M.: Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem Biophys Res Commun. 309(3), 558-566, 2003

9.

Fujinoki, M., Kawamura, T., Toda, T, Ohtake, H., Ishimoda-Takagi, T., Shimizu, N., Yamaoka,S., Okuno, M.: Identification of 36-kDa flagellar phosphoproteins associated with hamster sperm motility. J. Biochem. 113, 61-369, 2003

10.

Takashima M, Kuramitsu Y, Yokoyama Y, Iizuka N, Toda T, Sakaida I, Okita K, Oka M, Nakamura K.: Proteomic profiling of heat shock protein 70 family members as biomarkers for hepatitis C virus-related hepatocellular carcinoma. Proteomics 3(12), 2487-2493, 2003

11.

Kamino H, Hiratsuka M, Toda T, Nishigaki R, Osaki M, Ito H, Inoue T, Oshimura M.: Searching for genes involved in arteriosclerosis: proteomic analysis of cultured human umbilical vein endothelial cells undergoing replicative senescence. Cell Struct Funct. 28(6), 495-503, 2003

12.

Satouh Y, Padma P, Toda T, Satoh N, Ide H, Inaba K.: Molecula characterization of radial spoke subcomplex containing radial spoke protein 3 and heat shock protein 40 in sperm flagella of the ascidian Ciona intestinalis. Molecular Biology of the Cells, 16, 626-636 (2005).

  13. Morisawa H, Toda T.: Collaborative proteomics framework with XML databases and an integrated XML viewer for 2DPAGE. J Electrophoresis, 49(1), 35-38 (2005).
 
 
  14. Saeki K, Yasugi E, Okuma E, Breit SN, Nakamura M, Toda T, Kaburagi Y, Yuo A.: Proteomic analysis on insulin signaling in human hematopoietic cells: identification of CLIC1 and SRp20 as novel downstream effectors of insulin. Am J Physiol Endocrinol Metab. 289(3), E419-428, 2005.
 
 
  15. Miura Y, Kano M, Abe K, Urano S, Suzuki S, Toda T.: Age-dependent variations of cell response to oxidative stress: proteomic approach to protein expression and phosphorylation. Electrophoresis. 26(14), 2786-2796, 2005.
 
 
  16. Sato Y, Yamanaka H, Toda T, Shinohara Y, Endo T.: Comparison of hippocampal synaptosome proteins in young-adult and aged rats. Neurosci Lett. 382(1-2), 22-26, 2005.
 
 
  17. Feng D, Imasawa T, Nagano T, Kikkawa M, Takayanagi K, Ohsawa T, Akiyama K, Ishigami A, Toda T, Mitarai T, Machida T, Maruyama N.: Citrullination preferentially proceeds in glomerular Bowman's capsule and increases in obstructive nephropathy. Kidney Int. 68(1), 84-95, 2005.
 
 
  18. Nakamura M, Sakurai Y, Takeda Y, Toda T.: Comparative proteomics of flotillin-rich Triton X-100-insoluble lipid raft fractions of mitochondria and synaptosome from mouse brain. J Electrophoresis. 49(4), 77-83, 2005.
 
 
  19. Tahimic CG, Tomimatsu N, Nishigaki R, Fukuhara A, Toda T, Kaibuchi K, Shiota G, Oshimura M, Kurimasa A.: Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells. Biochem Biophys Res Commun. 340(4),1244-1250, 2006.
 
 
  20. Nakamura M, Yamada M, Ohsawa T, Morisawa H, Nishine T, Nishimura O, Toda T.: Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress. Biochem Biophys Acta 1763(9), 977-989, 2006.
 
 
  21. Morisawa H, Hirota M, Toda T.: Development of an open source laboratory information management system for 2-D gel electrophoresis-based proteomics workflow. BMC Bioinformatics 7:430-440, 2006.
 
 
  22. Hozumi A, Satouh Y, Makino Y, Toda T, Ide H, Ogawa K, King SM, Inaba K.: Molecular characterization of Ciona sperm outer arm dynein reveals multiple components related to outer arm docking complex protein 2. Cell Motil Cytoskeleton. 63(10), 591-603, 2006.
 
 
  23. Sato Y, Suzuki Y, Ito E, Shimazaki S, Ishida M, Yamamoto T, Yamamoto H, Toda T, Suzuki M, Suzuki A, Endo T.: Identification and characterization of an increased glycoprotein in aging: age-associated translocation of cathepsin D. Mech Ageing Dev. 127(10), 771-778, 2006.
 
 
  24. Nakahara M, Saeki K, Yogiashi Y, Kimura A, Horiuchi A, Nakamura N, Yoneda A, Saeki K, Matsuyama S, Nakamura M, Toda T, Kondo Y, Kaburagi Y, Yuo A.: The protein expression profile of cynomolgus monkey embryonic stem cells in two-dimensional gel electrophoresis: a successful identification of multiple proteins using human databases. J Electrophoresis 51(1), 1-8, 2007.
 
 
  25. 戸田年総 : 発生・老化研究法 --- 細胞老化 ---. 最新電気泳動実験法(日本電気泳動学会編), pp. 434-438,医歯薬出版, 1999
 
 

26.

戸田年総 : プロテオーム解析とインフォマテックス.二次元電気流動データベース(伊藤隆司/谷口寿章編), pp. 208-216, プロテオミクス, 中山書店, 2000

27.

戸田年総 : 老化のプロテオーム解析. 遺伝子医学, 4(4), 595-600, 2000

  28. 戸田年総 : プロテオームを利用した老化のプロファイリング. 実験医学, 18(18),2490-2496, 2000
 
 
  29. 戸田年総 : 肺のプロテオーム解析. The Lung Perspectives, 8(3), 294-297, 2000
 
 
  30. 戸田年総 : プロテオームデータベースの構築と活用. 生物物理化学, 44(3),181-184, 2000
 
 
  31. 戸田年総 : ゲノム情報とプロテオーム情報の統合によってもたらされる生命情報科学の新展開. 生物物理化学, 45(2), 139-142, 2001
 
 
  32. 戸田年総 : プロテオーム科学の展望. 日本老年医学雑誌, 39(1), 8-13, 2002
 
 
  33. 戸田年総 : プロテオームインフォーマティクス ---プロテオームデータベースの構築とその利用---. 医学のあゆみ, 202(5), 319-323, 2002
 
 
  34. 戸田年総 : 老化のしくみとプロテオミクス ---タンパク質の切り口からみた老化---. 医学のあゆみ, 202(5), 353-357, 2002
 
 
  35. 蔵満保宏、戸田年総、岡 正朗、沖田 極、中村和行:質量分析計によるタンパク質分子の多様性解析 --- 肝細胞癌グルタミン合成酵素の翻訳後修飾 ---. J. Mass Spectrom. Soc. Jpn., 51(5), 504-508, 2003
 
 
  36. 戸田年総:リン酸化タンパク質のプロテオーム解析. Molecular Medicine, 41(5), 530-537, 2004
 
 
  37. 戸田年総:タンパク質の加齢変化. 日本アフェレシス学会雑誌, 23(2), 135-142, 2004
 
 
  38. 秋山翹一、島田信子、木村成道、戸田年総: プロテオーム解析におけるリン酸化タンパク質の高感度分析法に関する基礎的検討とミエリン塩基性タンパク質への応用. 生物物理化学, 49(3), 73-81, 2005.
 
 
  39. 戸田年総: CJDと狂牛病に関する分子病理学. 安全医学, 2(2), 31-40,2006.
 
 
  40. 戸田年総: 細胞老化のプロセスを定量的ディファレンシャルプロテオミクスから探る. 分子呼吸器病, 10(2), 82-86, 2006.
 
 
  41. 戸田年総: 疾患プロテオミクス. ファルマシア, 42(1), 2006.
 
 
  42. 戸田年総: 老化のゲノミクスとプロテオミクス. 24(12), 1308-1312, 2006.
 
 
  43. 戸田年総: プロテオーム解析のための最新の質量分析装置. 生物物理化学, 51(1), 1-6, 2007.
 
 

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2007/05/15
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