財団法人東京都高齢者研究・福祉振興財団　東京都老人総合研究所
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老化ゲノムバイオマーカー研究チーム　

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レドックス制御
主要文献
　 1. Miyasaka, K., Nomoto, S., Ohta, M., Kanai, S., Kaneko, T., Tahara, S. and Funakoshi, A., Disturbance of response to acute thermal pain in naturally occurring cholecystokinin-a receptor gene knockout Otsuka Long-Evans Tokushima Fatty (OLETF) rats. J. Pharmacol. Sci. 101, 280-285, 2006
　		 　
　 2. Shinkai, T., Kobayashi, S., Urano, S., Yoshizawa,M., Nakajima, K. and Ishimaru, M., Effects of a dioxin on aging in wistar rats. AGE 28, 65-66, 2006
　		 　
　 3. Shinkai, T., Kondo,H., Kaneko, T., Tahara, S., Matsumoto, S., Sasaki, T., Kuramoto, K., Yanabe, M., Takagi, S., Ohta, M. and Miyasaka, K., Effects of Ghrelin on Longevity in Spontaneous Dwarf Rats. Reg. Pept. 135, 156, 2006
　		 　
　 4. Sasaki, T., Iwamoto, A., Tsuboi, H. and Watanabe, Y., Development of real-time bioradiographic system for functional and metabolic imaging in living brain tissue. Brain Res. 1077, 161-169, 2006
　		 　
　 5. Ogonovszky, H., Berkes, I., Kumagai, S., Kaneko, T., Tahara, S., Nakamoto, H., Goto, S. and Rad?k, Z., The effects of moderate-, strenuous-, and over-training on oxidative stress markers, DNA repair, and memory, in rat brain. Neurochem. Int., 46, 635-640, 2005
　		 　
　 6. Fukui, K., Takatsu, H., Shinkai, T., Suzuki, A., Abe, K. and Urano, S., Appearance of amyloid ?-like substances and delayed-type apoptosis in rat hippocampus CA1 region through aging and oxidative stress. J. Alzheimer's Disease 8, 299-309, 2005
　		 　
　 7. Sasaki, T., Yamaguchi, M. and Kojima, S., Demonstration of hyperaccumulation of [18F]2-fluoro-2-deoxy-D-glucose under oxygen deprivation in living brain slices using bioradiography. Synapse 55, 252-261, 2005
　		 　
　 8. Ogonovszky, H., Berkes, I., Kumagai, S., Kaneko, T., Tahara, S., Nakamoto, H., Goto, S. and Rad?k, Z., The effects of moderate-, strenuous-, and over-training on oxidative stress markers, DNA repair, and memory, in rat brain. Neurochem. Int. 46, 635-640, 2005
　		 　
　 9. Ogonovszky, H., Sasv?ru, M., Dosek, A., Berkes, I., Kaneko, T., Tahara, S., Nakamoto, H., Goto, S. and Rad?k, Z., The effects of moderate, strenuous, and overtraining on oxidative stress markers and DNA repair in rat liver. Can. J. Applied Physiol. 30, 186-195, 2005
　		 　
　 10. Kashiwagi, K., Shinkai, T., Kajii, E. and Kashiwagi, A., The effects of reactive oxygen species on amphibian aging. Comp. Biochem. Physiol. Part C 140, 197-205, 2005
　		 　

11.

Tahara, S., Baba, N., Matsuo, M. and Kaneko, T., Protective effect of epigallocatechin gallate and esculetin on oxidative DNA damage induced by psoralen plus ultraviolet-A therapy. Biosci. Biotechnol. Biochem. 69, 620-622, 2005

12.

Kaneko, T., Tahara, S., Takabayashi, F. and Harada, N., Suppression of 8-oxo-2'-deoxyguanosine formation and carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine in hamsters by esculetin and esculin. Free Radic. Res. 38, 839-846, 2004

13.

Onyango, A.N., Nakajima, S., Kaneko, T., Matsuo, M. and Baba, N., The rapid oxidative degradation of a phosphatidylcholine bearing an oxidatively modified acyl chain with a 2,4-dienal terminal. Chem. Phys. Lipids 131, 81-92, 2004

14.

Takabayashi, F., Tahara, S., Kaneko, T. and Harada, N., Accumulation of 8-oxo-2'-deoxyguanosine (as a biomarker of oxidative DNA damage) in the tissues of aged hamsters and change in antioxidant enzyme activities after single administration of N-nitrosobis(2-oxopropyl)amine. Gerontology 50, 57-63, 2004

15.

Tahara, S. and Kaneko, T., Susceptibility of mouse splenic cells to oxidative DNA damage by X-ray irradiation. Biol. Pharm. Bull. 27, 105-108, 2004

16.

Sasaki, T., In vivo and in vitro molecular imaging techniques to clarify the mechanism of oxidative stress related to brain aging and neurodegenerative diseases. Curr. Med. Chem. 4, 61-69, 2004

17.

Kaneko, T., Aging and the accumulation of oxidative damage to DNA. J. Clin. Biochem. Nutr. 34, 53-62, 2003

18.

Zhu, W., Umegaki, H., Shinkai, T., Kurotani, S., Suzuki, Y., Endo, H. and Iguchi, A., Different glial reactions to hippocamapl stab wounds in young adult and aged rats. J. Gerontol. 58A, 117-122, 2003

19.

Kaneko, T., Tahara, S. and Takabayashi, F., Protective effects of fluvastatin, an HMG-CoA reductase inhibitor, on the formation of 8-oxo-2'-deoxyguanosine in the nuclear DNA of hamster pancreas after a single administration of N-nitorosobis(2-oxopropyl)amine. Biol. Pharm. Bull. 26, 1245-1248, 2003

20.

Oka, T., Adati, N., Shinkai, T., Sakuma, K., Nishimura, T. and Kurose, K., Bisphenol A induces apoptosis in central neural cells during early development of Xenopus laevis. Biochem. Biophts. Res. Commun. 312, 877-882, 2003

21.

Kaneko, T., Tahara, S. and Takabayashi, F., Suppression of lipid hydroperoxide-induced oxidative damage to cellular DNA by esculetin. Biol. Pharm. Bull. 26, 840-844, 2003

22.

Onodera, K., Omoi, N., Fukui, K., Hayasaka, T., Shinkai, T., Suzuki, S., Abe, K. and Urano, S., Oxidative damage of rats cerebral cortex and hippocampus, and changes in antioxidative defense systems caused by hyperoxia. Free Radic. Res. 37, 367-372, 2003

23.

Ueda, J., Takeshita, K., Matsumoto, S., Yazaki, K., Kawaguchi, M. and Ozawa, T, Singlet oxygen-mediated hydroxyl radical production in the presence of phenols: whether DMPO-OH formation really indicates production of OH? Photochem. Photobiol. 77, 165-170, 2003

24.

Kaneko, T., Baba, N. and Matsuo, M., Protection of human endothelial cells against linoleic acid hydroperoxide-induced toxicity with coumarins. Chem. Biol. Interact. 142, 239-254, 2003

　 25. Sasaki, N., Toda, T., Kaneko, T., Baba, N. and Matsuo, M., Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells. Chem. Biol. Interact. 145, 101-116, 2003
　		 　
　 26. Kaneko, T., Tahara, S., Tanno, M. and Taguchi, T., Effect of age on the induction of 8-oxo-2'-deoxyguanosine-releasing enzyme in rat liver by -ray irradiation. Arch. Gerontol. Geriatr. 36, 23-35, 2003
　		 　

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財団法人東京都高齢者研究・福祉振興財団東京都老人総合研究所、トップページへ
2007/05/15
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