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トップページ > 研究紹介 >
老化ゲノムバイオマーカー研究チーム
> 老化制御
> 主要文献
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老化ゲノムバイオマーカー研究チーム
研究テーマ：
老化制御
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SMP30 |
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1.
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Ishigami, A. and Maruyama, N.: (REVIEW ARTICLE)
Significance of SMP30 in Gerontology. Geriatrics &
Gerontology International (2007) (in press)
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2.
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石神昭人 : ビタミンＣの不足が老化に及ぼす影響．ビタミン (2007) (in press)
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3.
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佐藤匡、瀬山邦明、石神昭人、丸山直記 : 肺の老化メカニズム．THE LUNG perspectives 15
155-160 (2007)
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4.
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Kondo, Y., Inai, Y., Sato, Y., Handa, S., Kubo, S.,
Shimokado, K., Goto, S., Nishikimi, M., Maruyama, N. and
Ishigami, A. : Senescence Marker Protein 30 Functions as
Gluconolactonase in L-Ascorbic Acid Biosynthesis and Its
Knockout Mice Are Prone to Scurvy. Proc. Nat. Acad. Sci. USA
103 5723-5728 (2006
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5.
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Sato, T., Seyama, K., Sato, Y., Mori, H., Souma, S.,
Akiyoshi, T., Kodama, Y., Mori, T., Goto, S., Takahashi, K.,
Fukuchi, Y., Maruyama, N. and Ishigami, A. : Senescence
Marker Protein-30 Protects Mice Lungs from Oxidative Stress,
Aging and Smoking. Am. J. Respir. Crit. Care Med. 174
530-537 (2006)
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6.
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Son, T.G., Zou, Y., Jung, K.J., Je, J.H., Yu, B.P.,
Ishigami, A., Maruyama, N. and Lee, J. : The increased
protein oxidation and the altered expression of Ca2+
regulatory proteins in senescence marker protein 30
deficient brain. Mech. Aging Dev.127 451-457 (2006)
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7.
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Jung, K.J., Chung, H.Y. Maruyama, N., Ishigami, A. and
Yu, B.P. : The redox-sensitive DNA binding sites responsible
for age-related downregulation of SMP30 by ERK pathway and
reversal by calorie restriction. Antioxid. Redox Signal. 8
671-680 (2006)
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8.
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石神昭人、佐藤安訓、丸山直記 : 機能解明！ SMP30はビタミンＣ合成に重要な酵素．基礎老化研究 30
11-14 (2006)
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9.
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石神昭人 : ビタミンCが不足すると老化が加速する
-機能性食品・サプリメント評価系への応用-．特別寄稿 FOODStyle21 10 30-33 (2006)
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10.
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Ishii, K., Tsubaki, T., Fujita, K., Ishigami, A.,
Maruyama, N., Akita, M. : Immunohistochemical localization
of senescence marker protein-30 (SMP30) in the submandibular
gland and ultrastructural changes of the granular duct cells
in SMP30 knockout mice. Histol. Histopathol. 20 761-768
(2005)
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11.
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丸山直記、石神昭人、近藤嘉高 : 老化の分子異常〜臨床検査医学への貢献．臨床病理53 728-734 (2005)
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12. |
森貴紀、瀬山邦明、石神昭人、丸山直記、福地義之助 : Senescence marker
protein-30ノックアウトマウス．分子呼吸器病 9 55-60 (2005)
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13. |
Ishigami, A., Fujita, T., Inoue, H., Handa, S., Kubo, S.,
Kondo, Y. and Maruyama, N. : Senescence Marker Protein-30
(SMP30) induces formation of microvilli and bile canaliculi
in Hep G2 cells. Cell & Tissue Res. 320 243-249 (2005)
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14. |
丸山直記、石神昭人、瀬山邦明: 「老化とCOPD」遺伝子から見た老化と臓器変化．COPD FRONTIER 3
9-12 (2004)
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15 |
Jung, K.J., Ishigami, A., Maruyama, N., Takahashi, R., Goto,
S., Yu B.P. and Chung, H.Y. : Modulation of gene expression
of SMP-30 by LPS and calorie restriction during aging
process. Exp. Gerontol. 39 1169-1177 (2004)
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16 |
Matsuyama, S., Kitamura, T., Enomoto, N., Fujita, T.,
Ishigami, A., Handa, S., Maruyama, N., Zheng, D., Ikejima,
K., Takei, Y. and Sato. N. : Senescence marker protein-30
(SMP30) regulates Akt activity and contributes to cell
survival in Hep G2 cells. Biochem. Biophys. Res. Commun. 321
386-390 (2004)
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17 |
Maruyama, N., Ishigami, A., Kuramoto, M., Handa, S., Kubo,
S., Imasawa, T., Seyama, K., Shimosawa, T., Kasahara, Y. :
Senescence Marker Protein-30 Knockout Mouse as an Aging
Model. Ann. NY Acad. Sci. 1019 383-387 (2004)
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18 |
Kondo, Y., Ishigami, A., Kubo, S., Handa, S., Gomi, K.,
Hirokawa, K., Kajiyama, N., Chiba, T., Shimokado, K. and
Maruyama, N. : Senescence marker protein-30 is a unique
enzyme that hydrolyzes diisopropyl phosphorofluoridate (DFP)
in the liver. FEBS Lett. 570 57-62 (2004)
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19 |
Mori, T., Ishigami, A., Seyama, K., Onai, R., Kubo, S.,
Shimizu, K., Maruyama, N. and Fukuchi, Y. : Senescence
marker protein-30 knockout mouse as a novel murine model of
senile lung. Pathol. Int. 54 167-173 (2004)
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20 |
Ishigami, A., Kondo, Y., Nanba, R., Ohsawa, T., Handa, S.,
Kubo, S., Akita, M. and Maruyama, N. : SMP30 deficiency in
mice causes an accumulation of neutral lipids and
phospholipids in the liver and shortens the life span.
Biochem. Biophys. Res. Commun. 315 575-580 (2004)
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PAD |
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1.
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Asaga, H. and Ishigami, A. : Microglial expression of
peptidylarginine deiminase 2 in prenatal rat brain. Cell.
Mol. Biol. Lett. (2007) (in press)
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2.
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丸山直記、石神昭人 : 蛋白質のシトルリン化と病態．最新医学60 2498-2501 (2005)
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3. |
丸山直記、石神昭人 : 老年病におけるシトルリン化蛋白質の病態生理学的意義．日本老年医学会雑誌42 519-522
(2005)
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4.
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Feng, D., Imasawa, T., Nagano, T., Kikkawa, M.,
Takayanagi, K., Ohsawa, T., Akiyama, K., Ishigami, A., Toda,
T., Mitarai, T., Machida, T. and Maruyama, N. :
Citrullination preferentially proceeds in glomerular
Bowman's capsule and increases in obstructive nephropathy.
Kidney Int. 68 84-95 (2005)
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5. |
Ishigami, A., Ohsawa, T., Hiratsuka, M., Taguchi, H.,
Kobayashi, S., Saito, Y., Murayama, S., Asaga, H., Toda, T.,
Kimura, N. and Maruyama, N. : Abnormal accumulation of
deiminated proteins catalyzed by peptidylarginine deiminase
in hippocampal extracts from patients with Alzheimer's
disease. J. Neurosci. Res. 80 120-128 (2005)
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6. |
石神昭人、 丸山直記 : シトルリン化蛋白質と関節リウマチ．医学のあゆみ 211 253-254 (2004)
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7. |
Guerrin, M., Ishigami, A., Mechin, MC., Nachat, R., Valmary,
S., Sebbag, M., Simon, M., Senshu, T. and Serre, G. : cDNA
cloning, gene organization and expression analysis of human
peptidylarginine deiminase type I. Biochem. J. 370 167-174
(2003)
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8. |
Ishigami, A., Asaga, H., Ohsawa, T., Akiyama, K. and
Maruyama, N. : Protein deimination and peptidylarginine
deiminase expression during cornification of rat epidermal
keratinocytes. Biomed. Res. 23 145-151 (2002)
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9. |
Ishigami, A., Ohsawa, T., Asaga, H., Akiyama, K., Kuramoto,
M. and Maruyama, N. : Human peptidylarginine deiminase type
II: Molecular cloning, gene organization and expression in
human skin. Arch. Biochem. Biophys. 407 25-31 (2002)
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10. |
Asaga, H., Akiyama, K., Ohsawa, T. and Ishigami, A. :
Increased and type II-specific expression of
peptidylarginine deiminase in activated microglia but not
hyperplastic astrocytes following kainic acid-evoked
neurodegeneration in the rat brain. Neurosci. Lett. 326
129-132 (2002)
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11. |
Ishigami, A., Asaga, H., Ohsawa, T., Akiyama, K. and
Maruyama, N. : Peptidylarginine deiminase type I, type II,
type III and type IV are expressed in rat epidermis. Biomed.
Res. 22 63-65 (2001)
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12. |
Asaga, H., Nakashima, K., Senshu, T., Ishigami, A. and
Yamada, M. : Immunocytochemical localization of
peptidylarginine deiminase in human eosinophils and
neutrophils. J. Leukocyte Biol. 70 46-51 (2001)
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13. |
Asaga, H. and Ishigami, A. : Protein deimination in the rat
brain after kainate administration: citrulline-containing
proteins as a novel marker of neurodegeneration. Neurosci.
Lett. 299 5-8 (2001)
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2007/05/11
Copyright(C)2007 Tokyo Metropolitan Institute of Gerontology. All rights reserved.
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