老化ゲノム機能-老年病・がんゲノム-主要文献

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老年病のゲノム解析研究チーム　

　研究テーマ：

老年病・がんゲノム

Aida J, Izumiyama-Shimomura N, Nakamura K, Ishii A, Ishikawa N, Honma
N, Kurabayashi R, Kammori M, Poon SS, Arai T, Takubo K. Telomere length variations in 6 mucosal cell types of gastric tissue observed using novel Q-FISH method. Hum Pathol 38: 2007 in press

Honma N, Takubo K, Akiyama F, Kasumi F, Sawabe M, Arai T, Hosoi T, Yoshimura　N, Harada N, Younes M, Sakamoto G. Expression of oestrogen receptor-beta in
apocrine carcinomas of the breast. Histopathology 50:425-433, 2007

Honma N, Takubo K, Arai T, Younes M, Kasumi F, Akiyama F, Sakamoto G. Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast. APMIS 114:712-719, 2006

Ishii A, Nakamura K, Kishimoto H, Honma N, Aida J, Sawabe M, Arai T, Fujiwara M, Takeuchi F, Kato M, Oshim
ura M, Izumiyama N, Takubo K.
Telomere shortening with aging in the human pancreas. Exp Gerontol 41:882-886, 2006

Takubo K, Arai T, Sawabe M, Arai T, Iwakiri K, Vieth M. Columnar-lined esophagus, Barrett's esophagus and adenocarcinoma: differences between east and west. Digest Endsc 18:S16-20, 2006

Honma N, Takubo K, Sawabe M, Arai T, Akiyama F, Sakamoto G, Utsumi T,　Yoshimura N, Harada N. Estrogen-metabolizing enzymes in breast cancers from　women over the age of 80 years. J Clin Endocrinol Metab 91:607-613, 2006

Honma N, Takubo K, Akiyama F, Sawabe M, Arai T, Younes M, Kasumi F, Sakamoto　G. Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast. Histopathology. 47:195-201, 2005

Takubo K, Shimomura-Izumiyama N, Koiwai H, Honma N, Esaki Y, Yoshida T, Nakajima T, Sawabe M, Arai T. Detection of human papillomavirus
infection of the cervix in the elderly women using PCR. Clin Cancer Res 11:2919-2923, 2005

Takubo K, Vieth M, Aryal G, Honma N, Sawabe M, Arai T, Kammori M, Mafune K, Iwakiri K. Islands of squamous epithelium and their surrounding mucosa in columnar-lined esophagus: a pathognomonic feature of Barrett's esophagus? Hum Pathol 36:269-274, 2005

10.

Takubo K, Vieth M, Honma N, Izumiyama N, Sawabe M, Arai T, Iwakiri K, Kammori M, Mafune K. Ciliated surface in the esophagogastric junction zone: a precursor of Barrett's mucosa or cilliated pseudostratified metaplasia? Am J Surg Pathol 29:211-217, 2005

11.

Takubo K, Honma N, Aryal G, Sawabe M, Arai T, Tanaka Y, Mafune K, Iwakiri K. Is there a set of histologic changes that are invariably reflux associated? Arch Pathol Lab Med 129:159-163, 2005

12.

Arai T, Esaki Y, Inoshita N, Sawabe M, Kasahara I, Kuroiwa K, Honma N, Takubo K. Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients. Gastric Cancer 7:154-159, 2004

13.

Fukushima M, Shimomura N, Nakamura K, Kammori M, Koizumi K, Shimizu K, Takubo K. Demonstration of human telomerase reverse transcriptase by in situ hybridization in lung carcinoma. Oncology Reports 12:1227-1232, 2004

14.

Arai T, Esaki Y, Sawabe M, Honma N, Nakamura K-I, Takubo K. Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly. Mod Pathol 17:172-179, 2004

15.

田久保海誉, 本間尚子, 新井冨生, 沢辺元司. 高齢者の癌の疫学と病理. ジェロントロジーニューホライズン 16:284-291, 2004

16.

神森　眞，田久保海誉. テロメア研究最近の進歩. 日本老年医学会雑 41: 365-368, 2004

17.

Honma N, Sakamoto G, Akiyama F, Esaki Y, Sawabe M, Arai T, Hosoi T, Harada N, Yones M, Takubo K. Breast carcinoma in women over the age of 85: distinct histological pattern and androgen, oestrogen, and prosterone receptor status. Histopathology 42:120-127, 2003
　

18.

Takubo K, Arai T, Sawabe M, Miyashita M, Sasajima K, Iwakiri K, Mafune K. Structure of the normal esophagus and Barrett's esophagus. Esophagus 1: 37-47, 2003
　

19.

Arai T, Nakahara K, Matsuoka H, Sawabe M, Chida H, Matsushita S, Takubo K, Honma N, Nakamura K, Izumiyama N, Esaki Y. Age-related mitochondrial DNA deletion in human heart: its relationship with cardiovascular diseases. Aging Clin Exp Res 15:1-5, 2003
　

20.

Kammori M, Nakamura K, Hashimoto M, Ogawa T, Kaminishi M, Takubo K. Clinical application of human telomerase reverse transcriptase gene expression in thyroid follicular tumors by fine-needle aspirations using in situ hybridization. Int J Oncol 22:985-991, 2003
　

21.

Takeuchi F, Harihara S, Nakamura K, Takubo K, Kanamori M, Goto M. The mitochondrial DNA A3243G mutation in Werner's syndrome. Exp Gerontol 38:339-342, 2003
　

22.

Kammori M, Nakamura K, Ogawa T, Mafune K-I, Tatutomi Y, Obara T, Onoda N, Fujiwara M, Izumiyama-Shimomura N, Mori M, Kaminishi M, Takubo K. Demonstration of human telomerase reverse transcriptase (hTERT) in human parathyroid tumours by in situ hybridization with a new oligonucleotide probe. Clin Endocrinol 58:43-48, 2003
　