老年病のゲノム解析研究チーム

　研究テーマ：

高齢者脳ゲノム

1.

 Saito Y, Geyer A, Sasaki R, Kuzuhara S, Nanba E, Miyasaka T, Suzuki K & Murayama S: Early onset, rapidly progressive familial tauopathy with R406W mutation. Neurology 2002; 58:811-813

2.

 Saito Y, Yamazaki M, Kanazawa I, Murayama S: Severe involvement of the ambient gyrus in a case of dementia with argyrophilic grain disease. J Neurol Sci 2002; 196: 71-75

3.

 Saito Y, Suzuki K, Nanba E, Yamamoto T, Ohno K, Murayama S: Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with ApoE e4 homozygosity. Ann Neurol. 2002: 52: 351-355

4.

 Saito Y, Nakahara K, Yamanouchi H, Murayama S: Severe Involvement of ambient gyrus in dementia with grains. Journal of Neuropathology and Experimental Neurology 2002; 61: 789-796

5.

 Kasahata N, Shiota J, Miyazawa Y, Nakano I, Murayama S: Acute human T-lymphotropic virus type I associated myelopathy - clinical and pathological study. Arch Neurol 2003; 60: 873-876

6.

 Saito Y, Kawashima A, Fujiwara H, Ruberu NN, Hasegawa M, Iwatsubo T, Murayama S: Accumulation of phosphorylated -synuclein in aging human brain. J Neuropath Exp Neurol 2003; 62: 644-654

7.

 Saito Y, Ruberu NN, Harada M, Arai T, Sawabe M, Nukina N, Murayama S: In-situ detection of apolipoprotein E e4 in archival human brain. Neuroreport 2004; 15: 1113-1115

8.

 Ruberu NN, Saito Y, Honma N, Sawabe M, Yamanouchi H Murayama S: Granulomatous meningitis as a late complication of iodized oil myelography. Neuropathology 2004; 24: 144-148

9.

 Saito Y, Suzuki K, Huelette C, Murayama S: Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease. J Neuropath Exp Neurol 2004; 63: 323-328

10.

 Murayama S, Saito Y: Neuropathological diagnostic criteria for Alzheimer disease. Neuropathology 2004; 24: 254-260

11.

 Saito Y, Ruberu NN, Sawabe M, Arai T, Kazama H, Hosoi T, Yamanouchi H Murayama S: Lewy body-related alpha-synucleinopathy in aging. J Neuropath Exp Neurol 2004; 63: 742-749

12.

 Saito Y, Ruberu NN, Sawabe M, Arai T, Tanaka N, Kakuta Y, Yamanouchi H, Murayama S: Staging of argyrophilic grains, an age-associated tauopathy. J Neuropath Exp Neurol 2004; 63: 911-918