βアミロイド神経毒性の分子機構-主要文献

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老年病のゲノム解析研究チーム

　研究テーマ：

βアミロイド神経毒性の分子機構

Uchida Y, Nakano SI, Gomi F, Takahashi H: Differential regulation of bHLH factors mash1 and olig2 by beta-amyloid accelerates both differentiation and the death of cultured neural stem/progenitor cells. J Biol Chem. ,282, 19700-19709, 2007

Hayashi Y, Hashizume T, Wakida K, Sato M, Uchida Y, Watabe K, Matsuyama Z, Kimura A, Inuzuka T, Hozumi I: Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis. ALS and other motor neuron disorders 7, 22-26, 2006

Gomi F, Nakano S, Uchida Y: Tolerance of aged rat brain to mild hyperoxia: Possible involvement of higher GIF content. Brain Res, 1033, 113-116, 2005

Hozumi I, Asanuma M, Yamada M, Uchida Y: Metallothioneins and neuro-degenerative diseases. J Health Sci, 50, 323-331, 2004

Sakamoto T, Kawazoe Y, Uchida Y, Hozumi I, Inuzuka T and Watabe K: Growth inhibitory Factor prevents degeneration of injured adult rat motoneurons. Neuroreport, 14, 2147-2151, 2003

Uchida Y: Overexpression of full length but not N-terminal truncated Isoform of microtubule-associated protein 1B accelerates apoptosis of cultured cortical neurons. J Biol Chem, 278, 366-371, 2003

Tanji K, Irie Y, Uchida Y, Mori F, Satoh K, Mizushima Y, Wakabayashi K: Expression of metallothionein-III induced by hypoxia attenuates hypoxia-induced cell death in vitro. Brain Res, 976, 125-129, 2003

Uchida Y, Gomi F, Masumizu T, Miura Y: Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging. J Biol Chem, 277, 32353-9, 2002

特許出願：

内田洋子（発明者）、特願2004-375422（日本）　「アルツハイマー病の検出方法」