　トップページ > 研究紹介 > 研究チーム紹介・健康長寿ゲノム探索研究チーム > 主要文献

健康長寿ゲノム探索研究チーム

Alexe, G., Fuku, N., Bilal, E., Ueno, H., Nishigaki, Y., Fujita, Y., Ito, M., Arai, Y., Hirose, N., Bhanot, G. and Tanaka, M. : Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population. Hum. Genet., 121, 347-356, 2007

Fuku, N., Park, K.S., Yamada, Y., Nishigaki, Y., Cho, Y.M., Matsuo, H., Segawa, T., Watanabe, S., Kato, K., Yokoi, K., Nozawa, Y., Lee, H.K. and Tanaka, M.. Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am.J.Hum.Genet., 80, 407-415, 2007

Tanaka, M., Fuku, N., Nishigaki, Y., Matsuo, H., Segawa, T., Watanabe, S., Kato, K., Yokoi, K., Yamaguchi, S., Nozawa, Y. and Yamada, Y. : Women with mitochondrial haplogroup N9a are protected against metabolic syndrome. Diabetes, 56, 518-521, 2007

Nishigaki, Y., Yamada, Y., Fuku, N., Matsuo, H., Segawa, T., Watanabe, S., Kato, K., Yokoi, K., Yamaguchi, S., Nozawa, Y. and Tanaka, M. : Mitochondrial haplogroup N9b is protective against myocardial infarction in Japanese males. Hum.Genet., 120, 827-836, 2007

Nishigaki, Y., Yamada, Y., Fuku, N., Matsuo, H., Segawa, T., Watanabe, S., Kato K., Yokoi, K., Yamaguchi, S., Nozawa, Y. and Tanaka, M. : Mitochondrial haplogroup A is a genetic risk factor for atherothrombotic cerebral infarction in Japanese females. Mitochondrion, 7, 72-79, 2007

Fujita, Y., Ito, M., Nozawa, Y., Yoneda, M., Oshida, Y. and Tanaka, M. : CHOP (C/EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations, Mitochondrion, 7, 80-88: 2007,

Verma, M., Naviaux, R., Tanaka, M., Kumar, D., Franceschi, C. and Singh, K. : Mitochondrial DNA and cancer epidemiology. Cancer Res., 67, 437-439, 2007

Fuku, N., Ochiai, M., Terada, S., Fujimoto, E., Nakagama, H. and Tabata, I. : Effect of running training on DMH-induced aberrant crypt foci in rat colon,Med.Sci.Sports Exerc., 39, 70-74, 2007

Park, H., Togo, F., Watanabe, E., Yasunaga, A., Park, S., Shephard, R.J. and Aoyagi, Y. : Relationship of bone health to yearlong physical activity in older Japanese adults: cross-sectional data from the Nakanojo Study. Osteoporos Int., 18, 285-293, 2007

10.

Aoyagi, Y. and Shephard, R.J. : Steps per day: the road to senior health?. Sports Med., in press

11.

Togo, F., Aizawa, S., Arai, J., Yoshikawa, S., Ishiwata, T., Shephard, R.J. and Aoyagi, Y. : Influence on human sleep patterns of lo
wering and delaying the minimum core body temperature by slow changes in the thermal environment. Sleep., in press, 2007

12.

Yasunaga, A., Park, H., Watanabe, E., Togo, F., Park, S., Shephard, R.J. and Aoyagi, Y. : Development and evaluation of the physical activity questionnaire for elderly Japanese (PAQ-EJ): the Nakanojo Study. J Aging Phys Act., in press, 2007

13.

Yasunaga, A., Togo, F., Watanabe, E., Park, H., Shephard, R.J. and Aoyagi, Y. : Sex, age, season, and habitual physical activity of older Japanese: the Nakanojo Study. J Aging Phys Act., in press, 2007

14.

Szewczyk. N.J., Tillman, J., Conley, C.A., Granger, L., Segalat, L., Higashitan, A., Honda, S., Honda, Y., Kagawa, H., Adachi, R., Higashibata, A., Fujimoto, N., Kuriyama, K., Ishioka, N., Fukui, K., Baillie, D., Rose, A., Gasset, G., Eche, B., Chaput, D. and Viso, M, : Description of international Caenorhabditis elegans experiment first flight (ICE-FIRST). Adv. Space Res., in press, 2007

15.

Higashibata, A., Higashitani, A., Adachi, R., Kagawa, H., Honda, S., Honda, Y., Higashitani, N., Sasagawa, Y., Miyazawa, Y., Szewczyk, N.J., Connley, C.A., Fujimoto, N., Fukui, K., Shimazu, T., Kuriyama, K. and Ishioka, N. : Biochemical and molecular biological analyses of spaceflown nematodes in Japan, international Caenorhabditis elegans experiment first (ICE-first). Micrograv. Sci. Tech., in press, 2007

16.

Baillie, D.L.,Rose, A.M., Zhao, Y., Higashitani, A., Honda, S., Honda, Y., Kagawa, H., Higashibata, A., Fujimoto, N., Kuriyama, K., Ishioka, N., Fukui, K., Tillman, J., Conley, C., Granger, L., Segalat, L., Gasset, G., Eche, B., Szewczyk, N.J., Chaput, D. and Viso, M. : ICE-FIRST, international Caenorhabditis elegans experiment first flight on the space station. Micrograv. Sci. Tech., in press, 2007

17.

Kazuno, A.A., Munakata, K., Nagai, T., Shimozono, S., Tanaka, M., Yoneda, M., Kato, N., Miyawaki, A. and Kato, T. : Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics,"PLoS.Genet., e128, 2006

18.

Moriyama, M., Li, M.X., Kobayashi, K., Sinasac, D.S., Kannan, Y., Iijima, M., Horiuchi, M., Tsui, L.C., Tanaka, M., Nakamura, Y. and Saheki, T. : Pyruvate ameliorates the defect in ureogenesis from ammonia in citrin-deficient mice. J. Hepatol., 44, 930-938, 2006

19.

Hirano, M., Nishino, I., Nishigaki, Y. and Marti, R. : Thymidine phosphorylase gene mutations cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Intern. Med., 45, 1103, 2006

20.

Wu, J., Oka, J., Higuchi, M., Tabata, I., Toda, T., Fujioka, M., Fuku, N., Teramoto, T., Okuhira, T., Ueno, T., Uchiyama, S., Urata, K., Yamada, K., Ishimi, Y. : Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial. Metabolism, 55, 423-433, 2006

21.

Wu, J., Oka, J., Tabata, I., Higuchi, M., Toda, T., Fuku, N., Ezaki, J., Sugiyama, F., Uchiyama, S., Yamada, K. and Ishimi, Y. : Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial. J Bone Miner. Res., 21, 780-789, 2006

22.

Yoshiuchi, K., Nakahara, R., Kumano, H., Kuboki, T., Togo, F., Watanabe, E., Yasunaga, A., Park, H., Shephard, R.J. and Aoyagi, Y. : Yearlong physical activity and depressive symptoms in older Japanese adults: cross-sectional data from the Nakanojo Study. Am J Geriatr Psychiatry., 14, 621-624, 2006

23.

Yasunaga, A., Togo, F., Watanabe, E., Park, H., Shephard, R.J. and Aoyagi, Y. : Yearlong physical activity and health-related quality of life in older Japanese adults: the Nakanojo Study. J. Aging Phys. Act.,14, 288-301, 2006

24.

Umetsu, K., Tanaka, M., Yuasa, I., Adachi, N., Miyoshi, A., Kashimura, S., Park, K.S., Wei, Y.H., Watanabe, G. and Osawa, M. : Multiplex amplified product-length polymorphism analysis of 36 mitochondrial single-nucleotide polymorphisms for haplogrouping of East Asian populations. Electrophoresis, 26, 91-98, 2005

25.

Niemi, A.K., Moilanen, J.S., Tanaka, M., Hervonen, A., Hurme, M., Lehtimaki, T., Arai, Y., Hirose, N. and Majamaa, K. A : combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects. Eur. J. Hum. Genet., 13, 166-170, 2005

26.

Naoi, M., Maruyama, W., Shamoto-Naga,i M., Yi, H., Akao, Y. and Tanaka, M. : Oxidative stress in mitochondria: decision to survival and death of neurons in neurodegenerative disorders. Mol. Neurobiol., 31, 81-93, 2005

27.

Munakata, K., Bundo, M., Kato, T., Ono, H., Sakura, N., Oosaki, M., Waki, C., Tanaka, M. : Co-existing point mutations of mitochondrial DNA in a patient with a heart abnormality and Pearson syndrome-like symptoms. Am. J. Med. Genet., A 139, 162-164, 2005

28.

Kazuno, A.A., Munakata, K., Mori, K., Tanaka, M., Nanko, S., Kunugi, H., Umekage, T., Tochigi, M., Kohda, K., Sasaki, T., Akiyama, T., Washizuka, S., Kato, N. and Kato, T. : Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'. Psychiatry
Clin. Neurosci., 59, 497-503, 2005

29.

Guo, L.J., Oshida, Y., Fuku, N., Takeyasu, T., Fujita, Y., Kurata, M., Sato, Y., Ito, M. and Tanaka, M. : Mitochondrial genome polymorphisms associated with type-2 diabetes or obesity. Mitochondrion, 5, 15-33, 2005

30.

Mancuso, M., Ferraris, S., Nishigaki, Y., Azan, G., Mauro, A., Sammarco, P., Krishna, S., Tay, S.K., Bonilla, E., Romansky, S.G. , Hirano, M. and DiMauro, S.: Congenital or late-onset myopathy in patients with the T14709C mtDNA mutation. J. Neurol. Sci., 228, 93-97, 2005

31.

Hirano, M., Lagier-Tourenne, C., Valentino, M.L., Marti, R., and Nishigaki Y. Thymidine phosphorylase mutations cause instability of mitochondrial DNA. Gene, 354, 152-156, 2005

32.

Honda, Y. and Honda, S. : Oxidative stress, gene expression and lifespan. In Nutrigenomics: The Role of Oxidants and Antioxidants in Gene Expression (Rimbach, G.H. and Packer, L., eds.), pp. 67-96, Marcel Dekker, New York, 2005

33.

Kawano, T., Kataoka, N., Abe, S., Ohtani, M., Honda, Y., Honda, S. and Kimura, Y. : Lifespan extending activity of substances secreted by nematode Caenorhabditis elegans that include the dauer-inducing pheromone. Biosci. Biotechnol. Biochem., 69, 2479-2481, 2005