独立行政法人　東京都健康長寿医療センター　研究所(東京都老人総合研究所）
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老化機構研究チーム　

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分子機構研究
主要文献
1.  Akasaka-Manya, K., Manya, H., Hayashi, M., and Endo, T. Different roles of the two components of human protein O-mannosyltransferase, POMT1 and POMT2. Biochem. Biophys. Res. Commun., 411, 721-725, 2011.
2.  Akasaka-Manya, K., Manya, H., Mizuno, M., Inazu, T., and Endo, T. Effects of length and amino acid sequence of O-mannosyl peptides on substrate specificity of protein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGnT1). Biochem. Biophys. Res. Commun., 410, 632-636, 2011.
3.  Clarke, N.F, Maugenre, S., Vandebrouck, A., Andoni Urtizberea, J., Willer, T., Peat, R., Gray, F., Bouchet, C., Manya, H., Vuillaumier-Barrot , S., Endo, T., Chouery, E., Campbell, K.P., Mégarbané, A., and Guicheney, P. Congenital muscular dystrophy type 1D (MDC1D) due to a large intragenic insertion/deletion involving intron 10 of the LARGE gene. Eur. J. Hum. Genet., 19, 452-457, 2011.
4.  Miura, Y., Sato, Y., Arai, Y., Abe, Y., Takayama, M., Toda, T., Hirose, N., and Endo, T. Proteomic analysis of plasma proteins in Japanese semisuper centenarians. Exp. Gerontol., 46, 81-85, 2011.
5.  Kanagawa, M., Omori, Y., Sato, S., Kobayashi, K., Miyagoe-Suzuki, Y., Takeda, S., Endo, T., Furukawa, T., and Toda, T. Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. J. Biol. Chem., 285, 31208-31216, 2010.
6.  Endo, T. A route from glycobiology to congenital muscular dystrophy. Trends Glycosci. Glycotech., 22, 152-161, 2010.
7.  Manya, H., Akasaka-Manya, K., Nakajima, A., Kawakita, M., and Endo, T. Role of N-glycans in maintaining the activity of protein O-mannosyltransferases POMT1 and POMT2. J. Biochem., 147, 337-344, 2010.
8.  Miura, Y., and Endo, T. Survival responses to oxidative stress and aging. Geriatr. Gerontol. Int., 10(Suppl. 1), S1-S9, 2010.
9.  Sato, Y., and Endo, T. Alteration of brain glycoproteins during aging. Geriatr. Gerontol. Int., 10(Suppl. 1), S32-S40, 2010.
　 10.  Manya, H., Akasaka-Manya, K., and Endo, T. Klotho protein deficiency and aging. Geriatr. Gerontol. Int., 10(Suppl. 1), S80-S87, 2010.
　		 　
　 11.  Akasaka-Manya, K., Manya, H., Sakurai, Y., Wojczyk, B.S., Kozutsumi, Y., Saito, Y., Taniguchi, N., Murayama, S., Spitalnik, S.L., and Endo, T. Protective effect of N-glycan bisecting GlcNAc residues on β-amyloid production in Alzheimer’s disease. Glycobiology, 20, 99-106, 2010.

 　
　 12.  Miura, Y., Sakurai, Y., Hayakawa, M., Shimada, Y., Zemple, H., Sato, Y., Hisanaga, S., and Endo, T. Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes. Biol. Pharm. Bull., 33, 22-28, 2010.

 　
　 13.  Miyagoe-Suzuki, Y., Masubuchi, N., Miyamoto, K., Wada, M., Yuasa, S., Saito, F., Matsumura, Kanesaki, H., Kudo, H., K., Manya, H., Endo, T., and Takeda, S. Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro. Mech. Dev., 126, 107-116, 2009.

 　
　 14.  Kanagawa, M., Nishimoto, A., Chiyonobu, T., Takeda, S., Miyagoe-Suzuki, Y., Wang, F., Fujikake, N., Taniguchi, M., Lu, Z., Tachikawa, M., Nagai, Y., Tashiro, F., Miyazaki, J., Tajima, Y., Takeda, S., Endo, T., Kobayashi, K., Campbell, K.P., and Toda, T. Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel models to dystroglycanopathy. Hum. Mol. Genet., 18, 621-631, 2009.

 　
　 15.  Akasaka-Manya, K., Manya, H., Sakurai, Y., Wojczyk, B.S., Spitalnik, S.L., and Endo, T. Increased bisecting and core fucosylated N-glycans on mutant human amyloid precursor proteins. Glycoconjugate J., 25, 775-786, 2008.
　		 　
　 16.  Kubota, K., Sato, Y., Suzuki, Y., Goto-Inoue, N., Toda, T., Suzuki, M., Hisanaga, S., Suzuki, A., and Endo, T. Rapid analysis of glycopeptides using lectin affinity chromatography with MALDI-TOF mass spectrometry. Anal. Chem., 80, 3693-3698, 2008.
　		 　
　 17.  Manya, H., Bouchet, C., Yanagisawa, A., Vuillaumier-Barrot, S., Quijano-Roy, S., Suzuki, Y., Maugenre, S., Richard, P., Inazu, T., Merlini, L., Romero, N., Leturcq, F., Bezier, I., Topaloglu, H., Estournet, B., Seta, N., Endo, T., and Guicheney, P. Protein O-mannosyltransferase activities in lymphoblasts from patients with α-dystroglycanopathies. Neuromuscul. Disord., 18, 45-51, 2008.
　		 　
　 18.  Manya, H., Suzuki, T., Akasaka-Manya, K., Ishida, H., Mizuno, M., Suzuki Y., Inazu, T., Dohmae, N. and Endo, T. Regulation of mammalian protein O-mannosylation: Preferential amino acid sequence for O-mannose modification. J. Biol. Chem., 282, 20200-20206, 2007.
　		 　
　 19.  Miura, Y., Kano, M., Suzuki, S., Endo, T., and Toda, T. Proteomic study on X-irradiation-responsive proteins and aging: Search for responsible proteins for radiation adaptive response. J. Biochem., 142, 145-155, 2007.
　		 　
　 20.  Akasaka-Manya, K., Manya, H., Nakajima, A., Kawakita, M., and Endo, T. Physical and functional association of human protein O-mannosyltransferases 1 and 2. J. Biol. Chem., 281, 19339-19345, 2006.

 　
　 21.  脳老化に伴う糖鎖の変化と老化関連疾患　遠藤玉夫　生化学　83巻3号,197-204,2011.

 　
　 22.  α-ジストログリカノパチーと糖鎖　遠藤玉夫　生体の科学　62巻2号,83-87,2011.

 　
　 23.  老化ゲノム機能からポストゲノム機能へ　遠藤玉夫　生体の科学　61巻6号,630-635,2010.

 　
　 24.  福山型筋ジストロフィーとその類縁疾患における病態：糖鎖による生体調節とその破綻　遠藤玉夫　化学と生物　47巻4号,244-252,2009.
　		 　

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独立行政法人　東京都健康長寿医療センター　研究所(東京都老人総合研究所）、トップページへ
2011/11/21
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