老化バイオマーカー研究-主要文献

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老化バイオマーカー研究

Nakane K, Fujita Y, Terazawa R, Atsumi Y, Kojima K, Nozawa Y, Deguchi T, Ito M. Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells. Int J Urol in press

Honda Y, Fujita Y, Maruyama H, Araki Y, Ichihara K, Sato A, Kojima T, Tanaka M, Nozawa Y, Ito M, Honda S. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS ONE 6 e23527 2011.

Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y, Ito M. Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem Biophys Res Commun 411:143-149, 2011.

Hamada N, Tanaka A, Fujita Y, Itoh T, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Akao Y, Nozawa Y, Ito M. Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H₂O₂-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds. Bioorg Med Chem 19:1959-1965, 2011.

Terazawa R, Garud DR, Hamada N, Fujita Y, Itoh T, Nozawa Y, Nakane K, Deguchi T, Koketsu M, Ito M. Identification of organoselenium compounds that possess chemopreventive properties in human prostate cancer LNCaP cells. Bioorg Med Chem 18:7001-7008, 2010.

Kojima K, Fujita Y, Nozawa Y, Deguchi T, Ito M. MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms. Prostate 70:1501-1512, 2010.

Fujita Y, Kojima K, Ohhashi R, Hamada N, Nozawa N, Kitamoto A, Sato A, Kondo S, Kojima T, Deguchi T, Ito M. MiR-148a attenuates paclitaxel-resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression. J Biol Chem 285:19076-19084, 2010.

Tanaka A, Hamada N, Fujita Y, Itoh T, Nozawa Y, Iinuma M, Ito M. A novel kavalactone derivative protects against H₂O₂-induced PC12 cell death via Nrf2/ARE activation. Bioorg Med Chem 18:3133-3139, 2010.

Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y, Ito M. Molecular hydrogen suppresses FcεRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun 389: 651-656, 2009.

10.

Hamada N, Fujita Y, Tanaka A, Naoi M, Nozawa Y, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Ito M. Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway. J Neural Transm 116:841-852, 2009.
　

11.

Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neurosci Lett 453:81-85, 2009.

12.

Fujita Y, Kojima K, Hamada N, Ohhashi R, Akao Y, Nozawa Y, Deguchi T, Ito M. Effects of miR-34a on Cell growth and chemoresistance in prostate cancer PC3 cells. Biochem Biophys Res Commun 377:114-119, 2008.

13.

Kojima K, Ohhashi R, Fujita Y, Hamada N, Akao Y, Nozawa Y, Deguchi T, Ito M. A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. Biochem Biophys Res Commun　373:423-428, 2008.

14.

Umemura K, Itoh T, Hamada N, Fujita Y, Akao Y, Nozawa Y, Matsuura N, Iinuma M, Ito M. Preconditioning by sesquiterpene lactone enhances H₂O₂-induced Nrf2/ARE activation. Biochem Biophys Res Commun 368:948-954, 2008.

15.

Fujita Y, Ito M, Nozawa Y, Yoneda M, Oshida Y, Tanaka M. CHOP (C/EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations. Mitochondrion 7:80-88, 2007.
　

16.

Russell TA, Ito M, Ito M, Yu RN, Martinson FA, Weiss J, Jameson JL. A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin producing neurons. J Clin Invest 112:1697-1706, 2003.
　

17.

Achermann JC, Ito M, Ito M, Hindmarsh PC, Jameson JL. A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. Nat Genet 22:125-126, 1999.
　

18.

Yu RN, Ito M, Saunders TL, Camper SA, Jameson JL. Role of Ahch in gonadal development and gametogenesis. Nat Genet 20:353-357, 1998.
　

19.

Ito M, Jameson JL, Ito M. Molecular basis of autosomal dominant neurohypophyseal diabetes insipidus: cellular toxicity caused by the accumulation of mutant vasopressin precursors within the endoplasmic reticulum. J Clin Invest 99:1897-1905, 1997.
　

20.

Ito M, Yu RN, Jameson JL. DAX-1 inhibits SF-1-mediated transactivation via a carboxyterminal domain that is deleted in adrenal hypoplasia congenita. Mol Cell Biol 17:1476-1483, 1997.
　

21.

Ito M, Oiso Y, Murase T, Kondo K, Saito H, Chinzei T, Racchi M, Lively MO. Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidus. J Clin Invest 91:2565-2571, 1993.
　

22.

Ito M, Mori Y, Oiso Y, Saito H. A single base substitution in the coding region for neurophysin II associated with familial central diabetes insipidus. J Clin Invest 87:725-728, 1991
　