老化機構研究チーム　

　研究テーマ：

レドックス研究

1.

 Sasaki, T., Shimizu, T., Koyama, T., Sakai, M., Uchiyama, S., Kawakami, S., Noda, Y., Shirasawa, T., and Kojima, S., Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia-reoxygenation. J. Neurosci. Res., 89, 601-10, 2011

2.

 Sasaki T., Unno K., Tahara S., Kaneko T., Age-related increase of reactive oxygen generation in the brains of mammals and birds: Is reactive oxygen a signaling molecule to determine the aging process and life span? Geriatr. Gerontol. Int. 10, S10-24, 2010

3.

 Kuramoto, K., Tahara, S., Sasaki, T., Matsumoto, S., Kaneko, T., Kondo, H., Yanabe, M., Takagi, S., Shinkai, T., Spontaneous dwarf rat: A novel model for aging research. Geriatr. Gerontol. Int., 10, 94-101, 2010

4.

 Sasaki, T., Sato, K., Umeda, I., Tahara, S., Kaneko, T., Effects of aging and every-other-day feeding on the levels of oxygen radicals in rat brain. Neurosci. Lett., 469, 84-87, 2010

5.

 Kuwahara H., Horie T., Ishikawa S., Tsuda C., Kawakami S., Noda Y., Kaneko T., Tahara S., Tachibana T., Okabe M., Melki J., Takano R., Toda T., Morikawa D., Nojiri H., Kurosawa H., Shirasawa T., Shimizu T., Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy. Free Radic. Biol. Med., 48, 1252-1262, 2010

6.

 Kawakami, S., Matsuda, A., Sunagawa, T., Noda, Y., Kaneko, T., Tahara, S., Hiraumi, Y., Adachi, S., Matsui, H., Ando, K., Fujita, T., Maruyama, N., Shirasawa, T., Shimizu, T., The antioxidant EUK-8 prevents murine dilaed cardiomyopathy. Cir. J., 73, 2125-2134, 2009

7.

 Watanabe, M., Yanagisawa, M., Furuno, N., Kashiwagi, K., Hanada, H., Shinkai, T., Yositome, S., Kubo, H., Sakai, M., Fujii, H., Yamashita, M., Kasiwagi, A., Analysis of head-defects in Xenopus embryss raised under hyoergravity condition Space Utiliz. Res., 25, 155-158, 2009

8.

 Shimizu, R., Nagai, A., Tominaga, H., Imura, M., Arnold N Onyango, AN, Izumi, M., Nakajima, S., Tahara, S., Kaneko, T., Baba, N., A combination of molecular probe-tandem electrospray ionization mass spectrometry: a technique for tracing structural changes in phospholipid hydroperoxides. Biosci. Biotechnol. Biochem., 73, 781-784, 2009

9.

 Sasaki, T., Unno, K., Tahara, S., Shimada, A., Chiba, Y., Hoshino, M., Kaneko, T., Age-related increase of superoxide generation in the brains of mammals and birds. Aging Cell, 7, 459-469, 2008

 Kondo, Y., Sasaki, T., Sato, Y., Amano, A., Aizawa, S., Iwama, M., Handa, S., Shimada, N., Fukuda, M., Akita, M., Lee, J., Jeong, K., Maruyama, N., Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice. Biochem. Biophys. Res. Commun., 377, 291-296, 2008
　

 Unno, K., Ishikawa, Y., Takabayashi, F., Sasaki, T., Takamori, N., Iguchi, K., Hoshino, M., Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice. Biofactors, 34, 263-271, 2008

 Shinkai, T., Kashiwagi, A., Furuno, N., Kashiwagi, K., Hanade, H., Kubo, H., Yoshitome, K., Watanabe, M., Fujii, H., Itai, M., Yamashita, M., Effects of Thyroxin on the Malfunction of the Pituitary-Thyroid Axis by Exposing Hypergravity in the Frog, Xenopus tropicana. Space Utiliz. Res., 24, 2008

 Oka, T., Tooi, O., Mitsui, N., Miyahara, M., Ohnishi, Y., Takase, M., Kashiwagi, A., Shinkai, T., Santo, N., Iguchi, T., Effect of atrazine on metamorphosis and sexual differentiation in Xenopus laevis. Aquat Toxicol., 87, 215-226, 2008

 Kumagai, T., Tanaka, M., Yokoyama, M., Sato, T., Shinkai, T., Furukawa, K., Early lethality of beta-1, 4-galactosyltransferase V-mutant mice by growth retardation. Biochem. Biophys. Res. Commun., 379, 456-459, 2008

 Sasaki, T., Nariai, T., Maehara, T., Sato, K., Oda, K., Ishii, K., A comparative study of bioradiography in human brain slices and preoperative PET imaging. Brain Res., 1142, 19-27, 2007.
　

 Shinkai, T., Matsuda, M., Kashiwagi, A., Kashiwagi, K., Furuno, N., Urano, S., Kubo, H., Itai, M., Fujii, H., Yamashita, M., Effects of Hypergravity on the Hypothalamus-Pituitary Axis in the Frog, Xenopus laevis. Space Utiliz. Res., 23, 311-313, 2007
　

 Nakamoto, H., Kaneko, T., Tahara, S., Hayashi, E., Naito, H., Radak, Z., Goto, S., Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats. Exp. Gerontol., 42, 287-295, 2007
　

 Kaneko, T., Tahara, S., Takabayashi, F., Inhibitory effect of natural coumarin compounds, esculetin and esculin, on oxidative DNA damage and formation of aberrant crypt foci and tumors induced by 1,2-dimethylhydrazine in rat colons. Biol. Pharm. Bull., 30, 2052-2057, 2007
　

 Shinkai, T., Kobayashi, S., Urano, S., Yoshizawa, M., Nakajima, K., Ishimaru, M., Effects of a dioxin on aging in wistar rats. AGE, 28, 65-66, 2006
　

 Sasaki, T., Iwamoto, A., Tsuboi, H., Watanabe, Y., Development of real-time bioradiographic system for functional and metabolic imaging in living brain tissue. Brain Res. 1077, 161-169, 2006