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老化機構研究チーム　

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　プロテオーム研究

Morisawa H, Toda T.: Collaborative proteomics framework with XML databases and an integrated XML viewer for 2DPAGE. J Electrophoresis, 49(1), 35-38, 2005.

Miura Y, Kano M, Abe K, Urano S, Suzuki S, Toda T.: Age-dependent variations of cell response to oxidative stress: proteomic approach to protein expression and phosphorylation. Electrophoresis. 26(14), 2786-2796, 2005.

Sato Y, Yamanaka H, Toda T, Shinohara Y, Endo T.: Comparison of hippocampal synaptosome proteins in young-adult and aged rats. Neurosci Lett. 382(1-2), 22-26, 2005.

Feng D, Imasawa T, Nagano T, Kikkawa M, Takayanagi K, Ohsawa T, Akiyama K, Ishigami A, Toda T, Mitarai T, Machida T, Maruyama N.: Citrullination preferentially proceeds in glomerular Bowman's capsule and increases in obstructive nephropathy. Kidney Int. 68(1), 84-95, 2005.

Nakamura M, Sakurai Y, Takeda Y, Toda T.: Comparative proteomics of flotillin-rich Triton X-100-insoluble lipid raft fractions of mitochondria and synaptosome from mouse brain. J Electrophoresis. 49(4), 77-83, 2005.

Tahimic CG, Tomimatsu N, Nishigaki R, Fukuhara A, Toda T, Kaibuchi K, Shiota G, Oshimura M, Kurimasa A.: Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells. Biochem Biophys Res Commun. 340(4),1244-1250, 2006.

Nakamura M, Yamada M, Ohsawa T, Morisawa H, Nishine T, Nishimura O, Toda T.: Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress. Biochem Biophys Acta 1763(9), 977-989, 2006.

Morisawa H, Hirota M, Toda T.: Development of an open source laboratory information management system for 2-D gel electrophoresis-based proteomics workflow. BMC Bioinformatics 7:430-440, 2006.

Sato Y, Suzuki Y, Ito E, Shimazaki S, Ishida M, Yamamoto T, Yamamoto H, Toda T, Suzuki M, Suzuki A, Endo T.: Identification and characterization of an increased glycoprotein in aging: age-associated translocation of cathepsin D. Mech Ageing Dev. 127(10), 771-778, 2006.

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Hashimoto R, Toda T, Tsutsumi H, Ohta M, Mori M: Abnormal N-Glycosylation of the Immunoglobulin G κ Chain in a Multiple Myeloma Patient with Crystalglobulinemia. Int. J. Hematol., 85(3), 203-206, 2007.

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Miura Y, Kano M, Yamada M, Nishine T, Urano S, Suzuki S, Endo T, Toda T.: Proteomic Study on X-irradiation-responsive Proteins and Ageing: Search for Responsible Proteins for Radiation Adaptive Response. J Biochem (Tokyo), 142(2), 145-155, 2007.

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Toda T, Nakamura M, Morisawa H, Hirota M.: Proteomic identification of oxidative-stress-reporting biomarkers differentially secreted from human neuroblastoma SH-SY5Y cells. J Electrophoresis, 51(3/4), 21-26, 2007.

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Kurosaki H, Kazuki Y, Hiratsuka M, Inoue T, Matsui Y, Wang, CC, Kanatsu-Shinohara M, Shinohara T, Toda T., Oshimura M.: A comparison study in the proteomic signatures of multipotent germline stem cells, embryonic stem cells, and germline stem cells. Biochem Biophys Res Comm, 353, 259-267, 2007.
　

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Akama K, Tatsuno R, Otsu M, Horikoshi T, Nakamura M, Toda T, Inoue N.: Proteomic identification of differentially expressed genes in ouse neural stem cells and neurons differentiated from embryonic stem cells in vitro. Biochim. Biophys. Acta, 1784, 773-782, 2008.
　

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Toda T, Nakamura M, Yamada M, Nishine T, Torii T, Ikenaka K, Hashimoto R, Mori M.: Glycoproteomic analysis of abnormal N-glycosylation on the kappa chain of cryocrystalglobulin in a patient of multiple myeloma. J Electroph, 53(1), 1-6, 2009.
　

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Nakamura M, Morisawa H, Imajoh-Ohmi S, Takamura C, Fukuda H, Toda T.: Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: An increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress. Exp Gerontol 44(6-7), 375-382, 2009.
　

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Tadokoro T, Ikekita M, Toda T, Ito H, Sato T, Nakatani R, Hamaguchi Y, Furukawa K.: Involvement of Galectin-3 with Vacular Cell Adhesion Molecule-1 in Growth Regulation of Mouse BALB/3T3 cells. J Biol Chem 284(51), 35556-35563, 2009.
　

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戸田年総: 老化のしくみとプロテオミクス　---タンパク質の切り口からみた老化---. 医学のあゆみ, 202(5), 353-357, 2002.
　

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戸田年総：タンパク質の加齢変化. 日本アフェレシス学会雑誌, 23(2), 135-142, 2004.
　

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秋山翹一、島田信子、木村成道、戸田年総: プロテオーム解析におけるリン酸化タンパク質の高感度分析法に関する基礎的検討とミエリン塩基性タンパク質への応用. 生物物理化学, 49(3), 73-81, 2005.
　

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戸田年総: 細胞老化のプロセスを定量的ディファレンシャルプロテオミクスから探る. 分子呼吸器病, 10(2), 82-86, 2006.
　

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戸田年総: 老化のゲノミクスとプロテオミクス. 病理と臨床, 24(12), 1308-1312, 2006.
　

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戸田年総: 血清蛋白質異常症のプロテオーム解析法. 検査と技術 35(7), 709-710, 2007.
　

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中村　愛、森澤　拓、戸田年総: ラミンＡ ---その多様な機能と老化. 基礎老化研究 33(4), 3-11, 2009
　