　トップページ > 研究紹介 > 老化制御研究チーム > 分子老化制御研究 > 分子老化制御研究A > 主要文献

老化制御研究チーム　

　研究テーマ：

分子老化制御研究A

Koike, K., Kondo, Y., Sekiya, M., Sato, Y., Tobino, K., Iwakami, S., Goto, S., Takahashi, K., Maruyama, N., Seyama, K. and Ishigami, A. : Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice. Am. J. Physiol. Lung Cell Mol. Physiol. (2010) (in press)

Amano, A., Aigaki, T., Maruyama, N. and Ishigami, A. : Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice. Arch. Biochem. Biophys. 496, 38-44 (2010)

Ishigami, A. and Maruyama, N.: (REVIEW ARTICLE) Importance of research on peptidylarginine deiminase and citrullinated proteins in age-related disease. Geriatr. Gerontol. Int. (2010) (in press)

Park, JK., Ki, MR., Lee, HR., Hong, IH., Ji, AR., shigami, A., Park, SI., Kim, JM., Chung, HY., Yoo, SE., Jeong, KS. : Vitamin C deficiency attenuates liver fibrosis via up-regulated PPAR-gamma expression in SMP30 knock-out mice. Hepatology (2010) (in press)

Park, JK., Hong, IH., Ki, MR., Chung, HY., Ishigami, A., Ji, AR., Goo, MJ., Kim, DH., Kwak, JH., Min, CW., Lee, SS., Jeong, KS. : Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice. J. Gastroenterol. Hepatol. (2010) (in press)

Ishigami, A. : Anti-aging Research Using SMP30/GNL Knockout Mice. Yakugaku Zasshi 130, 25-28 (2010)

Ishigami, A. and Manya, H. : Advanced Approaches to Anti - aging - Use of Aging Model. Yakugaku Zasshi 130, 1-2 (2010)

Shimada, N., Handa, S., Uchida, Y., Fukuda, M., Maruyama, N., Asaga, H., Choi, E.K., Lee J., and Ishigami, A. : Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain. J. Neurosci. Res. 88, 798-806 (2010)

Jang, B., Jin, JK., Jeon, YC., Cho, HJ., Ishigami, A., Choi, KC. Carp, RI., Maruyama, N., Kim, YS. and Choi, EK. : Involvement of peptidylarginine deiminase-mediated posttranslational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease. Acta Neuropatho. 119, 199-210 (2010)

10.

Hasegawa, G., Yamasaki, M., Kadono, M., Tanaka, M., Asano, M., Senmaru, T., Kondo, Y., Fukui, M., Obayashi, H., Maruyama, N., Nakamura, N. and Ishigami, A. : Senescence Marker Protein-30/Gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion. Endocrinology 151, 529-536 (2010)
　

11.

Sato, Y., Uchiki, T., Iwama, M., Kishimoto, Y., Takahashi, R. and Ishigami, A. : Determination of dehydroascorbic acid in mouse tissues and plasma by using tris(2-carboxyethyl)phosphine hydrochloride as reductant in metaphosphoric acid/ethylenediaminetetraacetic acid solution. Biol. Pharm. Bull. 33, 364-369 (2010)

12.

Park, H., Ishigami, A., Shima, T., Mizuno, M., Maruyama, N., Yamaguchi, K., Mitsuyoshi, H., Minami, M., Yasui, K., Itoh, Y., TYoshikawa, T., Fukui, M., Hasegawa, G., Nakamura, N., Ohta, M., Obayashi, H. and Okanoue, T. : Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease. J. Gastroenterol. (2009) (in press)

13.

Ogiwara, Y., Mori, S., Iwama, M., Sawabe, M., Takemoto, M., Kanazawa, N., Furuta, K., Fukuda, I., Kondo, Y., Kimbara, Y., Tamura, Y., Chiba, Y., Araki, A., Yokote, K., Maruyama, N., Hideki, I. : Hypoglycemia due to ectopic secretion of insulin-like growth factor-I in a patient with an isolated sarcoidosis of the spleen. Endocrine Journal (2009) (in press)

14.

Kashio, A., Amano, A., Kondo, Y., Sakamoto, T., Iwamura, H., Suzuki, M., Ishigami, A. and Yamasoba, T. : Effect of vitamin C depletion on age-related hearing loss in SMP30/GNL knockout mice. Biochem. Biophys. Res. Commun. 390, 394-398 (2009)

15.

Handa, S., Maruyama, N. and Ishigami, A. : Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 cells. Biol. Pharm. Bull. 32, 1645-1648 (2009)
　

16.

Fukuda, M., Kanou, F., Shimada, N., Sawabe, M., Saito, Y., Murayama, S., Hashimoto, M., Maruyama, N. and Ishigami, A. : Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease. Biomed. Res. 30, 227-233 (2009)
　

17.

18.

19.

20.

Arai, Y.K., Sato, Y., Kondo, Y., Kudo, C., Tsuchiya, H., Nomura, Y., Ishigami, A., and Nishiyama, T. : Effects of vitamin C deficiency on the skin of the senescence marker protein-30 (SMP30) knockout mouse. Biochem. Biophys. Res. Commun. 385 478-483 (2009)
　

21.

Son, T.G., Park, H.R., Kim, S.J., Kim, K., Kim, MS., Ishigami, A., Handa, S., Maruyama, N. Chung, H.Y. and Lee, J. : Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis. J. Neurosci. Res. (2009) (in press)
　

22.

Wakoh, T., Uekawa, N., Terauchi, K., Sugimoto, M., Ishigami, A., Shimada,J., Maruyama, M. : Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression Biochem Biophys Res Commun 380, 807-812 (2009)
　

23.

Kawakami, K., Ishigami, A., Goto, S., and Takahashi, R. : Age-related changes of histone modifications in rat liver. Biogerontology 10, 415-421 (2009)
　

24.

Kondo, Y., Sasaki, T., Sato, Y., Amano, A., Iwama, M., Handa, S., Shimada, N., Fukuda, M., Akita, M., Lee, J., Jeong, KS., Maruyama, N., Ishigami, A. : Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice. Biochem Biophys Res Commun 377, 291-296 (2008)
　

25.

Sato, Y., Kajiyama, S., Amano, A., Kondo, Y., Sasaki, T., Handa, S., Takahashi, R., Fukui, M., Hasegawa, G., Nakamura, N., Fujinawa, H., Mori, T., Ohta, M., Obayashi, H., Maruyama, N., Ishigami, A. : Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun 375, 346-50 (2008)
　

26.

Jang B, Kim E, Choi JK, Jin JK, Kim JI, Ishigami A, Maruyama N, Carp RI,Kim YS Choi EK : Accumulation of citrullinated proteins by upregulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis. Am. J. Pathol. 173, 1131-1144 (2008)
　

27.

Furusawa, H., Sato, Y., Tanaka, Y., Inai, Y., Amano, A., Iwama, M., Kondo, Y., Handa, S., Murata, A., Nishikimi, M., Goto, S., Maruyama, N., Takahashi, R. and Ishigami, A. : Vitamin C is not essential for carnitine biosynthesis in vivo: Verification in vitamin C-depleted SMP30/GNL knockout mice. Biol. Pharm. Bull. 31, 1673-1679 (2008) [Highlighted paper selected by Editor-in chief]
　

28.

Park, JK., Jeong, DH., Park, HY., Son, KH., Shin, DH., Do, SH., Yang, HJ., Yuan, DW., Hong, IH., Goo, MJ., Lee, HR., Ki, MR., Ishigami A, and Jeong, KS. : Hepatoprotective effect of Arazyme on CCl4-induced acute hepatic injury in SMP30 knock-out mice. Toxicology 256, 132-142 (2008)
　