老化制御研究チーム　

　研究テーマ：

分子老化制御研究B

1.

 Takahashi, M., Shimizu, T., Moriizumi, E. & Shirasawa, T. Clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos. Mech Ageing Dev 129, 291-8 (2008).

2.

 Kim, J., Takahashi, M., Shimizu, T., Shirasawa, T., Kajita, M., Kanayama, A. & Miyamoto, Y. Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans. Mech Ageing Dev 129, 322-31 (2008).9

3.

 Baba, T., Shimizu, T., Suzuki, Y., Ogawara, M., Isono, K., Koseki, H., Kurosawa, H. and Shirasawa, T. Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice. J Biol Chem, 280 (16), 16417-16426 (2005).

4.

 Nakai, D., Shimizu, T., Nojiri, H., Uchiyama, S., Koike, H., Takahashi, M., Hirokawa, K. and Shirasawa, T. coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q. Aging Cell, 3 (5), 273-281 (2004).

5.

 Nakai, D., Yuasa, S., Takahashi, M., Shimizu, T., Asaumi, S., Isono, K., Takao, T., Suzuki, Y., Kuroyanagi, H., Hirokawa, K., Koseki, H., and Shirasawa, T. Mouse homologue of coq7/clk-1, longevity gene in Caenorhabditis elegans, is essential for coenzyme Q synthesis, maintenance of mitochondrial integrity, and neurogenesis. Biochem Biophys Res Commun 289, 463-471 (2001).

6.

 Takahashi, M., Asaumi, S., Honda, S., Suzuki, Y., Nakai, D., Kuroyanagi, H., Shimizu, T., Honda, Y., and Shirasawa, T. coq7/clk-1 Orthologue Rescued Slowed Rhythmic Behavior and Extended Life Span of clk-1 Longevity Mutant in Caenorhabditis elegans. Biochem Biophys Res Commun 286, 534-540 (2001).

7.

 高橋真由美、白澤卓二．CoQ10は有効か？基礎研究から見たコエンザイムQ(CoQ)の機能．アンチエイジング医学 3 (3), 60-63 (2007).