独立行政法人　東京都健康長寿医療センター　研究所(東京都老人総合研究所）
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老化制御研究チーム　

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環境老化研究
主要文献
　 　 （２０１１年以降） 　
1.  Terasaki, Y., Ohsawa, I., Terasaki, M., Takahashi, M., Kunugi, S., Dedong, K., Urushiyama, H., Amenomori, S., Kaneko-Togashi, M., Kuwahara, N., Ishikawa, A., Kamimura, N., Ohta, S., Fukuda, Y. (2011) Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am. J. Physiol. Lung Cell Mol. Physiol. 301, L415-426
2.  Kamimura, N., Nishimaki, K., Ohsawa, I., Ohta, S. (2011) Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity. 19, 1396-1403
3.  Mitsuishi, T., Kabashima, K., Tanizaki, H., Ohsawa, I., Oda, F., Yamada, Y., Halifu, Y., Kawana, S., Kato, T., Iida, K. (2011) Specific substance of Maruyama (SSM) suppresses immune responses in atopic dermatitis-like skin lesions in DS-Nh mice by modulating dendritic cell functions. J. Dermatol. Sci. 63, 184-190
4.  大澤郁朗 (2011) 水素分子医学の現状と展望．基礎老化研究 35, 1-7
5.   高橋真由美 (2011) 寿命：究極の生体リズム. ファルマシア 47, 654-658
　 　
（２０１０年）		 　
6.  Wu, I.-C., Ohsawa, I., Fuku, N., and Tanaka, M. (2010). Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function. Anal. N.Y. Academy Sci. 1201, 111-120.
7.  Wolf, AM., Asoh, S., Hiranuma, H., Ohsawa, I., Iio, K., Satou, A., Ishikura, M., and Ohta, S. (2010). Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J. Nutr. Biochem. 21, 381-389.
8.   Mitsuishi, T., Iwabu, Y., Tokunaga, K., Sata, T., Kaneko, T., Ohara, K., Ohsawa, I., Oda, F., Yamada, Y., Kawana, S., Ozaki, K., Nakatake, M., and Yamada, O. (2010). Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors. BMC Cancer 10:118, doi:10.1186/1471-2407-10-118.
9.  Nakajima, S., Ohsawa, I., Ohta, S., Ohno, M., and Mikami, T. (2010). Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. Behav. Brain Res. 211, 178-184.
10.  Oharazawa, H., Igarashi, T., Yokota, T., Fujii, H., Suzuki, H., Machide, M., Takahashi, H., Ohta, S., and Ohsawa, I. (2010). Rapid Diffusion of Hydrogen Protects the Retina: Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury. Invest. Ophthalmol. Vis. Sci. 51, 487-492.
11.  大澤郁朗. (2010). 酸化ストレス防御系の破綻とアルツハイマー型認知症．医学のあゆみ 232, 698-704.
12.  Takahashi, M. and Shirasawa, T. (2010). Functions of the gerontogene clk-1 in mammals. Biomedical Gerontology 34, 25-31
　 　
（２００９年）		 　
13.  Endo, J., Sano, M., Katayama, T., Hishiki, T., Shinmura, K., Morizane, S., Matsuhashi, T., Katsumata, Y., Zhang, Y., Ito, H., Nagahata, Y., Marchitti, S., Nishimaki, K., Wolf, A.M., Nakanishi, H., Hattori, F., Vasiliou, V., Adachi, T., Ohsawa, I., Taguchi, R., Hirabayashi, Y., Ohta, S., Suematsu, M., Ogawa, S., and Fukuda, K. (2009). Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res. 105, 1118-1127.
14.  Nakashima, Y., Ohsawa, I., Konishi, F., Hasegawa, T., Kumamoto, S., Suzuki, Y., and Ohta, S. (2009). Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice. Neurosci. Lett. 464, 193-198.
15.  Suzuki, Y., Sano, M., Hayashida, K., Ohsawa, I., Ohta, S., and Fukuda, K. (2009). Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett. 583, 2157-2159.
16.  Nakajima, S., Ohsawa, I., Nagata, K., Ohta, S., Ohno, M., Ijichi, T., and Mikami, T. (2009). Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory. Behav. Brain Res. 200, 15-21.
17.  Fu, Y., Ito, M., Fujita, Y., Ito, M., Ichihara, M., Masuda, A., Suzuki, Y., Maesawa, S., Kajita, Y., Hirayama, M., Ohsawa, I., Ohta, S., and Ohno, K. (2009). Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci. Lett. 453, 81-85.
18.  Nagata, K., Nakashima-Kamimura, N., Mikami, T., Ohsawa, I., and Ohta, S. (2009). Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsycopharmacology. 34, 501-508.
19.  Murakami, Y., Ohsawa, I., Kasahara, T., and Ohta, S. (2009). Cytoprotective role of mitochondrial amyloid β peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde. Neurobiol. Aging. 30, 325-329.
20.  Harita, Y., Kurihara, H., Kosako, H., Tezuka, T., Sekine, T., Igarashi, T., Ohsawa, I., Ohta, S., and Hattori, S. (2009). Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-γ1. J. Biol. Chem. 284, 8951-8962.
21.  Nakashima-Kamimura, N., Mori, T., Ohsawa, I., Asoh, S., and Ohta, S. (2009). Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother. Pharmacol. 64, 753-761.
　 　
（２００８年）		 　
22.  Ohsawa, I., Nishimaki, K., Murakami, Y., Suzuki, Y., Ishikawa, M., and Ohta, S. (2008). Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial ALDH2 activity. J. Neurosci. 28, 6239-6249.
23.  Wolf, A.M., Asoh, S., Ohsawa, I., and Ohta, S. (2008). Imaging mitochondrial redox environment and oxidative stress using a redox-sensitive fluorescent protein. J. Nippon Med. Sch. 75, 66-67.
24.  Katsura, K.I., Takahashi, K., Asoh, S., Watanabe, M., Sakurazawa, M., Ohsawa, I., Mori, T., Igarashi, H., Ohkubo, S., Katayama, Y., and Ohta, S. (2008). Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. J. Neurochem. 106, 258-270.
25.  Watanabe, M., Katsura, K.I., Ohsawa, I., Mizukoshi, G., Takahashi, K., Asoh, S., Ohta, S., and Katayama, Y. (2008). Involvement of mitoK(ATP) channel in protective mechanisms of cerebral ischemic tolerance. Brain Res. 1238, 199-207.
26.  Hayashida, K., Sano, M., Ohsawa, I., Shinmura, K., Tamaki, K., Kimura, K., Endo, J., Katayama, T., Kawamura, A., Kohsaka, S., Makino, S., Ohta, S., Ogawa, S., and Fukuda, K. (2008). Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem. Biophys. Res. Commun. 373, 30-35.
27.  Ohsawa, I., Nishimaki, K., Yamagata, K., Ishikawa, M., and Ohta, S. (2008). Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem. Biophys. Res. Commun. 377, 1195-1198.
　 28.  Kogiku, M., Ohsawa, I., Matsumoto, K., Sugisaki, Y., Takahashi, H., Teramoto, A., and Ohta, S. (2008). Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor. J. Clin. Neurosci. 15, 1198-1203.
　		 　
　 29.  大澤郁朗, 太田成男 (2008). 加 齢. 日本臨床66増刊1, 169-174.
　		 　
　 30.  村上弥生, 大澤郁朗, 太田成男 (2008). ミトコンドリアに局在するAβ結合アルコール脱水素酵素による酸化ストレスからの防御機構. 日本臨床 66増刊1, 113-119.
　		 　
　 31.  太田成男, 大澤郁朗 (2008). 水素分子による新しい概念の抗酸化治療法と予防医学. 実験医学 26, 2074-2080.
　		 　
　 32.  Takahashi, M., Shimizu, T., Moriizumi, E. & Shirasawa, T. (2008). Clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos. Mech Ageing Dev 129, 291-8.
　		 　
　 33.  Kim, J., Takahashi, M., Shimizu, T., Shirasawa, T., Kajita, M., Kanayama, A. & Miyamoto, Y. (2008). Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans. Mech Ageing Dev 129, 322-31.
　		 　
　 　
（２００７年）		 　
　 34.  Fukuda, K., Asoh, S., Ishikawa, M., Yamamoto.Y., Ohsawa, I., and Ohta.S. (2007). Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem. Biophys. Res. Commun. 361, 670-674.
　		 　
　 35.  Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., Katsura, K.-I., Katayama, Y., Asoh, S., and Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat. Med. 13, 688-694.
　		 　
　 36.  高橋真由美、白澤卓二 (2007)．CoQ10は有効か？基礎研究から見たコエンザイムQ(CoQ)の機能．アンチエイジング医学 3, 60-63.
　		 　
　 　
（２００６年以前）		 　
　 37.  Nakai, D., Shimizu, T., Nojiri, H., Uchiyama, S., Koike, H., Takahashi, M., Hirokawa, K. and Shirasawa, T. (2004). coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q. Aging Cell, 3, 273-281.
　		 　

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独立行政法人　東京都健康長寿医療センター　研究所(東京都老人総合研究所）、トップページへ

2011/11/28
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