老年病理学研究チーム　

　研究テーマ：

高齢者がん研究

1.

  Honma N, Saji S, Hirose M, Horiguchi SI, Kuroi K, Hayashi SI, Utsumi T, Harada N. Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathogiological role of androstene-3β, 17β-diol. Cancer Sci. 2011 [Epub ahead of print]

2.

 相田順子、新井冨生、櫻井うらら、沢辺元司、田久保海誉. 食道炎、異型上皮、扁平上皮癌の鑑別診断　消化管の病理I -上部消化管-. 病理と臨床. 29(9): 926-931, 2011

3.

 Ishikawa N, Nakamura K, Izumiyama N, Aida J, Sawabe M, Arai T, Kishimoto H, Fujiwara M, Ishii A, Takubo K Telomere dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age. AGE. Online First, 7 July, 2011

4.

 新井冨生、相田順子、椙村春彦、馬場聡、田久保海誉. 日本臨床　増刊号6　食道癌　-基礎・臨床研究の進歩- IV.食道癌の病理　食道癌の病理学的分類 非上皮性良性・悪性腫瘍. 日本臨床 67(増6): 93-98, 2011

5.

 Aida J, Vieth M, Ell C, May A, Pech O, Hoshihara Y, Kumagai Y, Kawada K, Hishima T, Tateishi Y, Sawabe M, Arai T, Matsuura M, Takubo K. Palisade vessels as a new histologic marker of esophageal origin in ER Specimens from columnar-lined esophagus. Am J Surg Pathol. 35: 1140-1145, 2011

6.

 Ishikawa N, Nakamura K, Izumiyama-Shimomura N, Aida J, Ishii A, Goto M, Ishikawa Y, Asaka R, Matsuura M, Hatamochi A, Kuroiwa M, Takubo K. Accelerated in vivo epidermal telomere loss in Werner syndrome. Aging. 3: 417-429, 2011

7.

 Honma N, Arai T, Takubo K, Younes M, Tanaka N, Mieno M, Tamura K, Ikeda S, Sawabe M, Muramatsu M. Oestrogen receptor-beta CA repeat polymorphism is associated with incidence of colorectal cancer among females. Histopathology. 59: 216-224, 2011

8.

 Younes M, Honma N. Estrogen receptor-beta. Arch Pathol Lab Med.135: 63-66, 2011

9.

 Arai T, Aida J, Nakamura K, Ushio Y, Takubo K. Clinicopathologic characteristics of basaloid squamous carcinoma of the esophagus. Esophagus. 2011 [in press]

 Aida J, Yokoyama A, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K. Alcoholics show reduced telomere length in the oesophagus. J Pathol. 223: 410-416, 2011
　

 本間尚子　乳腺疾患の概要と鑑別診断上皮性腫瘍―癌および境界病変　アポクリン癌　癌診療指針のための病理診断プラクティス （青笹克之、黒住昌史編）中山書店　135-140, 2011

 Takubo K, Aida J, Izumiyama N, Ishikawa N , Fujiwara M,. Poon SSS, Kondo H, Kammori M, Matsuura M, Sawabe M, Arai T, Baird DM, Nakamura K. Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mech Age Dev. 131: 614-624, 2010
　

 Sonoda R, Naomoto Y, Shirakawa Y, Fujiwara Y, Yamatsuji T, Noma K, Tanabe S, Takaoka M, Gunduz M, Tsujigiwa H, Nagatsuka H, Ohara N, Yoshino T, Takubo K, Vieth M, Tanaka N. Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma. Histopathology. 57: 90-100, 2010
　

 相田順子、有馬美和子、新井冨生、沢辺元司、田久保海誉　Current Organ Topics: 食道・胃 癌　I. Barrett癌の病理学的最新知見　癌と化学療法 第37巻第9号, 1670-1673, 2010
　

 本間尚子、原田信広　エストロゲン代謝酵素群の役割　乳癌―基礎と臨床の架け橋―　最新医学　65巻　6月増刊号, 122-131, 2010
　

 新井冨生、櫻井うらら、沢辺元司、本間尚子、相田順子、田久保海誉. 大腸鋸歯状病変の病理診断. 病理と臨床　第28巻 (6), 613-618, 2010
　

 Takubo K, Aida J, Izumiyama-Shimomura N, Ishikawa N, Sawabe M, Kurabayashi R, Shiraishi H, Arai T, Nakamura K. Changes of telomere length with aging. Geriatr Gerontol Int. 10(s1): S197-S206, 2010
　

 Arai T, Kasahara I, Sawabe M, Honma N, Aida J, Takubo K. Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly. Geriatr Gerontol Int. 10(s1): S207-S212, 2010

 本間尚子（分担執筆）　第2部　組織型と診断の実際 1. 上皮性腫瘍 B. 悪性（腫瘍）2. 浸潤癌 b. 特殊型（7）アポクリン癌．　　黒住昌史，森谷卓也編集　腫瘍病理鑑別診断アトラス“乳癌”　文光堂, 98-101, 2010

 相田順子,　新井冨生,　田久保海誉．食道胃接合部．病理と臨床（臨時増刊号）病理形態学キーワード　第28巻 : 86-87, 2010

 Takubo K, Fujita M , Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Grabsch H, Arai T, Aida J. Q-FISH analysis of telomere and chromosome instability in theoesophagus with and without squamous cell carcinoma in situ. J Pathol 221:201-9, 2010
　

 Kumagai Y, Kawada K, Yamazaki S, Iida M, Ochiai T, Kawano T, Takubo K. Prospective replacement of magnifying endoscopy by a newly developed endocytoscope, the “GIF-Y0002” Dis Esophagus 23, 627-632, 2010
　

 Fiocca R, Mastracci L, Riddell R, Takubo K, Vieth M, Yerian L, Sharma P, Fernstrom P, Ruth M. Development of consensus guidelines for the histologic recognition of microscopic esophagitis in patients with gastroesophageal reflux disease: the Esohisto project. Hum Pathol 41:223-31, 2010