老年病理学研究チーム　

　研究テーマ：

神経病態生理研究

 Masuda, M., Miura, M., Imanishi, M., Saino-Saito, S., Inoue, R., Takada, M., Kobayashi, K., Aosaki, T. Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum. European Journal of Neuroscience, in press.

 Ageta, H., Ikegami, S., Miura, M., Masuda, M., Migishima, R., Hino, T., Takashima, N., Murayama, A., Sugino, H., Setou, M., Kida, S., Yokoyama, M., Yoshihisa Hasegawa, Y., Tsuchida, K., Aosaki, T. and Inokuchi, K. Activin Bi-directionally Controls the Fate of Fear Memory. Learning and Memory, 17: 176-185, 2010.

 Tomida, S., Mamiya, T., Sakamaki, H., Miura, M., Aosaki, T., Masuda, M., Niwa, M., Kameyama, T., Kobayashi, J., Iwaki, Y., Imai, S., Ishikawa, A., Abe, K., Yoshimura, T., Nabeshima, T., Ebihara, S. Identification of Usp46, encoding a ubiquitin specific peptidase, as a quantitative trait gene regulating mouse immobile behavior in the tail suspension test and the forced swimming test. Nature Genetics, 41(6): 688-695, 2009.

 Sato, T., Miura, M., Yamada, M., Yoshida, T., Wood, J.D., Yazawa, I., Masuda, M., Suzuki, T., Shin, R-M., Yau, H-J., Liu, F-C., Shimohata, T., Onodera, O., Ross, C.A., Katsuki, M., Takahashi, H., Kano, M., Aosaki, T., Tsuji, S. Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice. Human Molecular Genetics, 18(4):723-736, 2009

 Miura, M., Masuda, M., Aosaki, T. Roles of μ-opioid receptor in GABAergic synaptic transmission in the striosome and matrix compartment of the striatum. Molecular Neurobiology 37:104-115, 2008.

 Imai, Y., Inoue, H., Kataoka, A., Hua-Qin, W., Masuda, M., Ikeda, T., Tsukita, K., Soda, M., Kodama, T., Fuwa, T., Honda, Y., Kaneko, S., Matsumoto, S., Wakamatsu, K., Ito, S., Miura, M., Aosaki, T., Itohara, S., Takahashi, R. Pael receptor is involved in dopamine metabolism in the nigrostriatal system. Neuroscience Research 59:413-425, 2007.

 Miura, M., Saino-Saito, S., Masuda, M., Kobayashi, K., Aosaki, T. Compartment-specific modulation of GABAergic synaptic transmission by μ-opioid receptor in the mouse striatum with green fluorescence protein-expressing dopamine islands. Journal of Neuroscience 27: 9721-9728, 2007.

 Miura, M., Ishii, K., Aosaki, T., Sumikawa, K. Chronic nicotine treatment increases GABAergic input to striatal neurons. NeuroReport 17: 537-540, 2006.

 Tateno, M., Sadakata, H., Tanaka, M., Itohara, S., Shin, R-M., Miura, M., Masuda, M., Aosaki, T., Urushitani, M., Misawa, H., Takahashi, R. Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 and development of amyotrophic lateral sclerosis in a transgenic mouse model. Human Molecular Genetics, 13:2183-2196, 2004.

 Shin, R-M., Masuda, M., Miura, M., Sano, H., Shirasawa, T., Song, W-J., Kobayashi, K., Aosaki T. Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. Journal of Neuroscience 23(37):11662-11672, 2003.
　

 Miura, M., Watanabe, M., Offermanns, S., Simon, MI., Kano, M. Group I Metabotropic Glutamate Receptor Signaling via Galpha q/Galpha 11 Secures the Induction of Long-Term Potentiation in the Hippocampal Area CA1. Journal of Neuroscience 22 8379-8390, 2002.

 Nakajima, M., Miura, M., Aosaki, T., Shirasawa, T. Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro. Journal of Neurochemistry 78(4):807-814, 2001.

 Suzuki, T., Miura, M., Nishimura, K., Aosaki, T. Dopamine-dependent synaptic plasticity in the striatal cholinergic interneurons. Journal of Neuroscience 21:6492-6501, 2001.

 Kobayashi, K., Noda, Y., Matsushita, N., Nishii, K., Sawada, H., Nagatsu, T., Nakahara, D., Fukabori, R., Yasoshima, Y., Yamamoto, T., Miura, M., Kano, M., Mamiya, T., Miyamoto, Y., Nabeshima, T. Modest Neuropsychological Deficits Caused by Reduced Noradrenaline Metabolism in Mice Heterozygous for a Mutated Tyrosine Hydroxylase Gene. Journal of Neuroscience 20: 2418-2426, 2000.

 Tsubokawa, H., Miura, M., Kano, M. Elevation of intracellular Na+ induced by hyperpolarization at the dendrites of pyramidal neurons of mouse hippocampus. Journal of Physiology 517:135-142, 1999.
　

 Aosaki, T., Kiuchi, K., Kawaguchi, Y. Dopamine D1-like receptor activation excites rat striatal large aspiny neurons in vitro. Journal of Neuroscience 18: 5180-5190, 1998.
　

 Furuse, H., Waki, H., Kaneko, K., Fujii, S., Miura, M., Sasaki, H., Ito, KI, Kato, H., and Ando, S. Effect of the mono- and tetra-sialogangliosides, GM1 and GQ1b, on long-term potentiation in the CA1 hippocampal neurons of the guinea pig. Experimental Brain Research 123:307-314, 1998.
　

 Miura, M., Yoshioka, M., Miyakawa, H., Kato, H., and Ito, KI Properties of calcium spikes revealed during GABA-A receptor antagonism in hippocampal CA1 neurons from guinea pigs. Journal of Neurophysiology 78:2269-2279, 1997.
　

 Aosaki, T., Kawaguchi, Y. Actions of substance P on rat neostriatal neurons in vitro. Journal of Neuroscience 16: 5141-5153, 1996.
　

 Chen, Z., Ito, K., Fujii, S., Miura, M., Furuse, H., Sasaki, H., Kaneko, K., Kato, H., Miyakawa, H. Roles of dopamine receptors in long-term depression: enhancement via D1 receptors and inhibition via D2 receptors. Receptors Channels 4:1-8, 1996.
　

 Fujii, S., Kuroda, Y., Miura, M., Furuse, H., Sasaki, H., Kaneko, K., Ito, K., Chen, Z., Kato, H. The long-term supressive effect of prior activation of synaptic inputs by low-frequency stimulation on induction of long-term potentiation in CA1 neurons of guinea pig hippocampal slices. Experimental Brain Research 111:305-312, 1996.

 Aosaki, T., Kimura, M., Graybiel, A. M. Temporal and spatial characteristics of the tonically active neurons of the primate's striatum. Journal of Neurophysiology, 73: 1234-1252, 1995.

 Graybiel, A. M., Aosaki, T., Flaherty, A. W., Kimura, M. The basal ganglia and adaptive motor control. Science 265: 1826-1831, 1994.

 Aosaki, T., Graybiel, A. M., Kimura, M. Effects of the Nigrostriatal Dopamine System on Acquired Neural Responses in the Striatum of Behaving Monkeys. Science 265: 412-415, 1994.
　

 Aosaki, T., Tsubokawa, H., Ishida, A., Watanabe, K., Graybiel, A. M., Kimura, M. Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensory-motor conditioning. Journal of Neuroscience 14: 3969-3984, 1994.