神経画像研究チーム　

　研究テーマ：

脳機能研究

 Minamimoto R, Toyohara J, Seike A, Ito H, Endo H, Morooka M, Nakajima K, Mitsumoto T, Ito K, Okasaki M, Ishiwata K, Kubota K. ¹¹C-4DST PET/CT for proliferation imaging in non-small-cell lung cancer. J Nucl Med (in press).
　

 Toyohara J, Nariai T, Sakata M, Oda K, Ishii K, Kawabe T, Irie T, Saga T, Kubota K, Ishiwata K. Whole-body distribution and brain tumor imaging with ¹¹C-4DST: a pilot study. J Nucl Med 2011; 52: 1322-1325.
　

 Paul S, Khanpaur S, Rybczynska AA, Kwizera C, Sijbesma JWA, Ishiwata K, Willemsen ATM, Elsinga PH, Dierckx, RAJO, van Waarde A. Small-animal PET study of adenosine A₁ receptors in rat brain: Blocking receptors and raising extracellular adenosine. J Nucl Med 2011; 52: 1293-1300.
　

 Yamamoto Y, Toyohara J, Ishiwata K, Sano K, Yamamoto F, Mukai T, Maeda M. ¹¹C-Labeled analogs of indomethacin esters and amides for brain cyclooxygenase-2 imaging: radiosynthesis, in vitro evaluation and in vivo characteristics in mice. Chem Pharm Bull 2011; 59(8): 938-946.
　

5.

 Zhang J, Wu J, Toyohara J, Fujita Y, Chen H, Hashimoto K. Pharmacological haraterization of [³H]CHIBA-3007 binding to glycine transporter 1 in the rat brain. PLos ONE 2011; 6(6):e21322.

 Mishina M, Ishii K, Suzuki M, Kitamura S, Ishibashi K, Sakata M, Oda K, Hamamoto M, Kominami S, Kobayashi S, Katayama Y, Ishiwata K. Striatal distribution of dopamine transporters and dopamine D₂ receptors at different stages of Parkinson’s disease. – A CFT and RAC PET study– Neuroradiol J 2011; 24:235-241.
　

 Toyohara J, Ishiwata K, Sakata M, Wu J, Nishiyama S, Tsukada, Hashimoto K. In vivo evaluation of carbon-11-labeled non-sarcosine based glycine transporter 1 inhibitors in mice and conscious monkeys. Nucl Med Biol 2011; 38:517-527.
　

 Sakata M, Wu J, Toyohara J, Oda K, Ishikawa M, Ishii K, Hashimoto K, Ishiwata K. Biodistribution and radiation dosimetry of the α-7 nicotinic acetylcholine receptor ligand [¹¹C]CHIBA-1001 in humans. Nucl Med Biol 2011; 38: 443-448.
　

 Suzuki Y, Kiyosawa M, Wakakura M, Mochizuki M, Ishii K. Gray matter density increase in the primary sensorimotor cortex in long-term essential blepharospasm. Neuroimage 2011; 56: 1-7
　

 Ishibashi K, Ishii K, Oda K, Mizusawa H, Ishiwata K. Binding of pramipexole to extrastriatal dopamine D₂/D₃ receptors in the human brain: A positron emission tomography study using ¹¹C-FLB 457. PLoS ONE 2011; 6(3):e17723.
　

 Mishina M, Ishiwata K, Naganawa M, Kimura Y, Kitamura S, Suzuki M, Hashimoto M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kobayashi S, Katayama Y, Ishii K. Adenosine A_2A receptors measured with [11C]TMSX PET in the striata of Parkinson’s disease patients. PLoS ONE 2011; 6(2):e17338.
　

1.

 Sato Y, Murayama H, Yamada T, .Hasegawa T, Oda K, Unno Y, Yunoki A. Monte Carlo simulation of the standardization of ²²Na using scintillation detector arrays. Appl Radiat Isot 2010; 68: 1354-1357.

2.

 Hasegawa T, Oda K, Wada Y, Sato Y, Yamada T, Yoshida E, Murayama H, Saito K, Takeda T, Kikuchi K. A practical method of determining cross-calibration factors of PET scanners by moving a point-like ²²Na radioactive source. Ann Nucl Med 2010; 24:655-661

3.

 Shimada H, Sturnieks D, Endo Y, Kimura Y, Suzuki T, Oda K, Ishii K, Ishiwata K. Relationship between whole body oxygen consumption and skeletal muscle glucose metabolism during walking in older adults: FDG PET study. Aging Clin Exp Res 2010 Oct 5. [Epub ahead of print]

4.

 Wu J, Toyohara J, Tanibuchi Y, Fujita Y, Zheng J, Chen H, Matsuo M, Wang RF, Hashimoto K. Pharmacological characterization of [¹²⁵I]CHIBA-1006, a new radioligand for α7 nicotinic acetylcholine receptors, to rat brain membranes. Brain Res 2010; 1360:130-137.

5.

 Suzuki Y, Kiyosawa M, Mochizuki M, Ishiwata K, Ishii K. The pre-supplementary and primary motor areas generate thythm for voluntary eye opening and closing movements. Tohoku J Exp Med 2010; 222: 97-104

6.

 Kambe T, Motoi Y, Ishii K, Hattori N. Posterior cortical atrophy with [¹¹C]Pittsburgh compound B accumulation in the primary visual cortex. J Neurol 2010; 257: 469-471.

7.

 Hasegawa T, Yoshida E, Sato Y, Oda K, Wada Y, Yamada T, Yamaya T, Murayama H, Saito K. Point-like radioactive source with multiple absorber capsules for evaluating PET scanners. Ann Nucl Med 2010; 24: 427-432

8.

 Hosoda C, Nariai T, Ishiwata K, Ishii K, Matsushima Y, Ohno K. Correlation between focal brain metabolism and higher brain function in patients with Moyamoya disease. Int J Stroke 2010; 5: 367-373

 Tanibuchi Y, Wu J, Toyohara J, Fujita Y, Iyo M, Hashimoto K. Characterization of [³H]CHIBA-1001 binding to α7 nicotinic acetylcholine receptors in the brain from rat, monkey, and human. Brain Res 2010; 1348:200-208.
　

 Miyamoto T, Orimo S, Miyamoto M, Hirata K, Adachi T, Hattori R, Suzuki M, Ishii K. Follow-up PET studies in case of idiopathic REM sleep behavior disorder. Sleep Med 2010; 11: 100-101.

 Saito T, Nakamura M, Shimizu T, Oda K, Ishiwata K, Ishii K, Isse K. Neuroradiologic evidence of pre-synaptic and post-synaptic nigrostriatal dopaminergic dysfunction in idiopathic basal ganglia calcification: A case report. J Neuroimaging 2010; 20: 189-190.

 Ishibashi K, Kanemaru K, Saito Y, Murayama S, Oda K, Ishiwata K, Mizusawa H, Ishii K. Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson’s disease. Acta Neurol Scand 2010; 122: 46-51

 Toyohara T, Ishiwata K, Sakata M, Wu J, Nishiyama S, Tsukada H, Hashimoto K. In vivo evaluation of α7 nicotinic acetylcholine receptor agonists [¹¹C]A-582941 and [¹¹C]A-844606 in mice and conscious monkeys. PLoS ONE 2010 Feb 1;5(2):e8961.
　

 Emoto H, Suzuki Y, Wakakura M, Horie C, Kiyosawa M, Mochizuki M, Kawasaki K, Oda K, Ishiwata K, Ishii K. Photophobia in essential blepharospasm—A positron emission tomographic study. Mov Disord 2010; 25(4): 433-439.
　

 Ishibashi K, Ishii K, Oda K, Mizusawa H, Ishiwata K. Competition between ¹¹C-raclopride and endogenous dopamine in Parkinson’s disease. Nucl Med Commun 2010; 31(2): 159-166.
　

 Ishibashi K, Saito Y, Murayama S, Kanemaru K, Oda K, Ishiwata K, Mizusawa H, Ishii K. Validation of cardiac ¹²³I-MIBG scintigraphy in patients with Parkinson’s disease who were diagnosed with dopamine-PET. Eur J Nucl Med Mol Imaging 2010; 37(1): 3-11.
　

 Shimada H, Hirata T, Kimura Y, Naka T, Kikuchi K, Oda K, Ishii K, Ishiwata K. Suzuki T. Effects of a robotic walking exercise on walking performance in community-dwelling elderly adults. Geriatr Gerontol Int 2009; 9(4): 372-381.
　

 Oda K, Toyama H, Mashima Y, Ishii K, Kosaka T, Kimura Y, Fukushi M, Ishiwata K. A statistical clustering approach to visualizing the relationship between early and delayed images in whole-body FDG-PET. Radiolog Phy Tech 2009; 2:145-150.
　

 Nishioka K, Ross OA, Ishii K, Kachergus JM, Ishiwata K, Kitagawa M, MD, Kono S, Obi T, Mizoguchi K, Inoue Y, Imai H, Takanashi M, Mizuno Y, Farrer MJ, Hattori N. Expanding the clinical phenotype of SNCA duplication carriers. Mov Disord 2009; 2:145-150.
　

 Nariai T, Ishiwata K, Kimura Y, Inaji M, Momose T, Yamamoto T, Matsumura A, Ishii K, Ohno K. PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma. Appl Radiat Isot 2009; 67(7-8 Suppl): S348-50.
　

 Nojiri T, Nariai T, Aoyagi M, Senda M, Ishii K, Ishiwata K, Ohno K. Contributions of biological tumor parameters to the incorporation rate of L-[methyl-¹¹C]methionine into astrocytomas and oligodendrogliomas. J Neuro-Oncol 2009; 93: 233-241.
　

 Shimada H, Kimura Y, Lord SR, Oda K, Ishii K, Suzuki T, Ishiwata K. Comparison of regional lower limb glucose metabolism in older adults during warking. Scand J Med Sci Sports 2009; 19(3): 389-397.
　

 Rybczynska AA, Elsinga PH, Sijbesma JW, Ishiwata K, de Jong JR, de Vries EF, Dierckx, RA, van Waarde A Steroid hormones affect binding of the sigma ligand ¹¹C-SA4503 in tumor cells and tumor-bearing rats. Eur J Nucl Med Mol Imaging 2009; 36: 1167-1175.
　

 Tanaka Y, Nariai T, Momose T, Aoyagi M, Maehara T, Tomori T, Yoshino Y, Nagaoka T, Ishiwata K, Ishii K, and Ohno K. Glioma surgery using a multimodal navigation system with integrated metabolic images. J Neurosurgery 2009; 110: 163-172.

 QingGeLeTu, Suzuki Y, Kiyosawa M, Ishiwata K, Mochizuki M. Functional and neuroreceptor Imaging in bicuculline-induced dystonic rat brain. Tohoku J Exp Med 2009; 217(4): 313-320.

 Shiba K, Nishiyama S, Tsukada H, Ishiwata K, Kawamura K, Ogawa K, Mori H. The potential of (–)-o-[¹¹C]methylvesamicol for diagnosing cholinergic deficit dementia. Synapse 2009; 63: 167-171.

 Shidahara M, Seki C, Naganawa M, Sakata M, Ishikawa M, Ito H, Kanno I, Ishiwata K, Kimura Y. Improvement of likelihood estimation in Logan graphical analysis using maximum A posteriori for neuroreceptor PET imaging. Ann Nucl Med 2009; 23(2): 163-171.
　

 Horie C, Suzuki Y, Kiyosawa M, Mochizuki M, Wakakura M, Oda K, Ishiwata K, Ishii K. Decreased dopamine D₂ receptor binding in essential blepharospasm. Acta Neurol Scand 2009; 119(1): 49-54.
　

 Ishibashi K, Ishii K, Oda K, Kawasaki K, Mizusawa H, Ishiwata K. Regional analysis of the age-related decline in dopamine transporters and dopamine D₂ receptors in human striatum. Synapse 2008; 63: 282-290.
　

 Hashimoto M, Kawasaki K, Suzuki M, Mitani K, Murayama S, Mishina M, Oda K, Kimura Y, Ishiwata K, Ishii K, Inoue K. Pre- and post-synaptic nigrostriatal dopaminergic functions in multiple system atrophy. Neuroreport 2008; 19(2): 145-150.
　

 Naganawa M, Kimura Y, Yano J, Mishina M, Yanagisawa M, Ishii K, Oda K, Ishiwata K. Robust estimation of the arterial input function for Logan plots using an intersectional searching algorithm and clustering in positron emission tomography for neuroreceptor imaging. NeuroImage 2008; 40: 26-34.
　

 Ohta Y, Nariai T, Ishii K, Ishiwata K, Mishina M, Senda M, Hirakawa K, Ohno K. Voxel- and ROI-based statistical analyses of PET parameters for guidance in the surgical treatment of intractable nesial temporal lobe epilepsy. Ann Nucl Med 2008; 22(6): 495-503.
　

 Ishiwata K, Ishii K, Kimura Y, Kawamura K, Oda K, Sasaki T, Sakata M, Senda M. Successive positron emission tomography measurement of cerebral blood flow and neuroreceptors in the human brain: an ¹¹C-SA4503 study. Ann Nucl Med 2008; 22(5): 411-416.
　

 Kawasaki K, Ishii K, Saito Y, Oda K, Kimura Y, Ishiwata K. Influence of mild hyperglycemia on cerebral ¹⁸F-FDG distribution patterns calculated by statistical parametric mapping. Ann Nucl Med 2008; 22: 191-200.
　

 Mishina M, Ohyama M, Ishii K, Kitamura S, Kimura Y, Oda K, Kawamura K, Sasaki T, Kobayashi S, Katayama Y, Ishiwata K. Low density of sigma1 receptors in early Alzheimer’s disease. Ann Nucl Med 2008; 22: 151-156.
　

 Sakata M, Kimura Y, Naganawa M, Ishikawa M, Oda K, Ishii K, Hashimoto K , Chihara K, Ishiwata K. Shortened protocol in practical [¹¹C]SA4503-PET studies for the sigma1 receptor quantification. Ann Nucl Med 2008; 22: 143-146.
　

 Suzuki Y, Horie C, Kiyosawa M, Nariai T, Mochizuki M, Oda K, Kimura Y, Ishiwata K, Ishii K. Measurement of the ¹¹C-flumazenil binding in the visual cortex predicts the prognosis of hemianopia. J Neurol Sci 2008; 268(1-2): 102-107.
　

 Nojiri Y, Ishiwata K, QingGeLeTu, Tobiishi S, Sasada T, Yamamoto F, Mukai T, Maeda M. Radiosynthesis and biodistribution of a ¹⁸F-labeled analog of O-1302 for use in cerebral CB1 cannabinoid receptor imaging. Biol Pharmacol Bull 2008; 31(6): 1274-1278.
　

 Rybczynska AA, Elsinga PH, Ishiwata K, Dierckx, RA, van Waarde A. Cytotoxicity of sigma receptor ligands is associated with striking changes of cellular metabolism and virtually complete occupancy of the sigma-2 subpopulation. J Nucl Med 2008; 49: 2049-2056.
　

 Fukumitsu N, Ishii K, Kimura Y, Oda K, Hashimoto M, Suzuki M, Ishiwata K. Adenosine A1 receptors using 8-dicyclopropylmethyl-1-[¹¹C]methyl-3-propylxanthine PET in Alzheimer’s disease. Ann Nucl Med 2008; 22: 841-847.
　

 Shimada H, Suzuki T, Kimura Y, Takashi Hirata T, Sugiura M, Yosuke Endo Y, Yasuhara K, Shimada K, Kikuchi K, Oda K, Ishii K, Ishiwata K. Effects of an automated stride assistance system on walking parameters and muscular glucose metabolism in elderly adults. Br J Sports Med 2008; 42(11): 622-629.
　

 Paul S, Elsinga PH, Ishiwata K, Dierckx RAJO, van Waarde A. Adenosine A1 receptors in the central nervous system: their functions in health and disease, and possible elucidation by PET imaging. Curr Med Chem (in press).
　

 Toyohara J, Ishiwata K. Animal tumor models for PET in drug development. Ann Nucl Med (in press). 2011 Aug 31 [Epub ahead of print]
　

 van Waarde A, Rybzynska AA, Ramakrishnan NK, Ishiwata K, Elsinga PH, Dierckx RA. Sigma receptors in oncology: Therapeutic and diagnostic applications of sigma ligands. Curr Pharmaceut Design 2010; 16(31): 3519-3537
　

 Toyohara J, Hashimoto K. α7 Nicotinic receptor agonists: potential therapeutic drugs for treatment of cognitive Impairments in schizophrenia and Alzheimer’s disease. Open Med Chem J, 2010; 4: 37-56
　

 Toyohara J, Wu J, Hashimoto K. Recent development of radioligands for imaging ?7 nicotinic acetylcholine receptors in the brain. Curr Top Med Chem. 2010; 10:1544-1557.
　

 Nariai T : Positron emission tomography in moyamoya disease. In: Moyamoya Disease Update. Tominaga T. et al. eds. Springer-Verlag 2010, pp205-212
　

 van Waarde A, Ramakrishnan NK, Rybzynska AA, Elsinga PH, Ishiwata K, Nijholt IM, Luiten PG, Dierckx RA. The cholinergic system, sigma-1 receptors and cognition. Behav Brain Res 2010 Jan 7.  2011; 221(2): 543-54.
　

 Ishiwata K, Kimura Y, Oda K, Ishii K, Sakata M, Kawasaki K, Nariai T, Suzuki Y, Ishibashi K, Mishina M, Hashimoto M, Ishikawa M, Toyohara J. Development of PET radiopharmaceuticals and their clinical applications at the Positron Medical Center. Geriatr Gerontol Int 2010; 10(Suppl 1): S180-S196.
　

 Toyohara J, Ishiwata K. Animal models – Overview of animal models for tumors, brain diseases and genetics. In: Trends on the role of PET in drug development . Eds. Elsinga PH, van Waarde A, Paans AMJ, Dierckx RA. World Scientific Publishing Co (in press).
　

 Nariai T, Ishiwata K. Analysis and Imaging: PET. Sauerwein, Wittig, Moss, Nakagawa (Eds) Textbook of Neutron Capture Therapy, Springer, Heidelberg, Germany (in press).
　

 Toyohara J, Sakata M, Ishiwata K. Imaging of sigma1 receptors in the human brain using PET and [¹¹C]SA4503. CNS Agents Med Chem 2009; 9:190-196.
　

 Bauer A, Ishiwata K. Adenosine receptor ligands and PET imaging of the CNS. Handb Exp Pharmacol. 2009; 193: 617-642.
　

 Ishiwata K, Kubota K, Nariai T, Iwata R. Whole-body tumor imaging: [O-¹¹C]methyl-L-tyrosine/positron emission tomography. In: Cancer Imaging: Instrument and Application. Vol. 2, Hayat MA (ed), Amsterdam: Elsevier; 2008. pp.175-179.
　

 Mishina M. Positron Emission Tomography for Brain Research J Nippon Med Sch 2008; 75(2): 68-76
　

 Ishiwata K, Kimura Y, de Vries EFJ, Elsinga PH. PET tracers for mapping adenosine receptors as probes for diagnosis of CNS disorders. CNS Agents Med Chem 2007; 7: 57-77.
　

 Kimura Y, Naganawa M, Shidamara M, Ikoma Y, Watabe H. PET kinetic analysis — Pitfalls and a solution for the Logan plot. Ann Nucl Med 2007; 21(1): 1-8.
　

 Watabe H, Ikoma Y, Kimura K, Naganawa M, Shidahara M. PET Kinetic analysis — Compartmental Model. Ann Nucl Med 20(9), 583-588, 2006
　

 Hashimoto K, Ishiwata K. Sigma receptor ligands: Possible application as therapeutic drugs and as radiopharmaceuticals. Curr Pharm Design 2006; 12: 3857-3876.