Theme Leader :
Shogo Endo, Ph.D.
Shuichi Yanai, Ph.D., Ritsuko Inoue, Ph.D.
Associate Researcher :
Tomoko Arasaki, M.S.
neuron regeneration, gene expression, memory, learning, neuronal plasticity, rehabilitation, drug repurposing, signal transduction
One of attractive questions in the field of neuroscience is to understand the molecular mechanisms underlying memory. We can act only stimulus- response way if the neuronal network is fixed. However, we have neuronal plasticity (flexibility) in our brain to modify our behaviors and to survive in the ever-changing environment. The modified behaviors are stored as "Memories". We are attacking the mechanisms of memory by using multidisciplinary approaches.
Aging and diseases including Alzheimer's disease lead to impairment of memory. This causes burden to patients and their family. Revelation of the impaired memory mechanisms and its treatments need basic researches. The research will identify the targets for the medical treatment and provide basis for the coming regeneration medicine.