Theme Leader :
Kenji Ishii, M.D.
Ishibashi, Kenji, M.D., Ph.D., Kei Wagatsuma, R.T., M.Sci.
Adjunct Researcher :
Keiichi Oda, Ph.D., Yukihisa Suzuki, M.D., Ph.D., Motoki Inaji, M.D., Ph.D., Yasumasa Imai, M.D., Ph.D., Shihori Hayashi, M.D., Hatsumi Endo, R.N.
PET, aging, dementia, Alzheimer's disease, Parkinson's disease, cerebrovascular disorders, epilepsy, movement disorders, cerebral blood flow and metabolism, neuroreceptors.
1. Development of diagnostic methods for early, prodromal, and preclinical dementia
We construct a large set of brain image database with longitudinal observations, and develop tools to detect fine morphological / functional deviations from estimated normal aging to detect very early change in dementia. We collaborate with Brain Bank group to conduce PET-pathology comparison which enable us to establish clinical significance of PET examinations. We tackle not only Alzheimer's disease, but also non-Alzheimer type dementias such as dementia with Lewy bodies and tauopathies
2. Research on amyloid imaging for clinical implementation
In the mid-term plan of 2013-2017, we strongly promote research on amyloid imaging for the clinical implementations. We participate in multi-center dementia studies of national and international scales such as World Wide ADNI studies and DIAN-Japan study in which we are in charge of Amyloid PET Core. We promote clinical trials of diagnostic and therapeutic pharmaceuticals for dementia, and settle on a clinical guideline of amyloid imaging.
3. Application of PET techniques for clinical gerontology research and medicine
We apply various PET techniques to gerontology research in understanding normal brain function and its aging, and age related brain disorders. We also provide selected PET diagnostic methods as advanced medical service of the hospital.
Visiting Scientists: Naonori Ohno, M.D. (Tokyo Medical and Dental University), Etsuko Imabayashi, M.D., Ph.D. (National Center of Neurology and Psychiatry), Masahiko Suzuki, M.D., Ph.D. (Jikei University), Keiichi Kawasaki (Jikei University), Kazuhiro Ishii, M.D., Ph.D. (Tsukuba University), Tadanori Fukami, Ph.D. (Yamagata University), Toshimitsu Musha, Ph.D. (Brain Functions Laboratory)
Technical and administrative staff: Airin Onishi, R.N., Eisuke Haneda, Ph.D., Mika Tanaka, M.Sci.
Collaborating staff of TMGH: Aya M Tokumaru, M.D., Ph.D., Keigo Shimoji, M.D., Ph.D., Kimiteru Ito, M.D., Ph.D., Naoki Yokokawa, R.T., Tatsufumi Osawa, R.T., Makoto Senoo, Ph.C.