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 Molecular Glycobiology

 


Leader

Tamao Endo, Ph.D.

Members

Researchers: Hiroshi Manya, Ph.D. Keiko Akasaka, Ph.D. Yoko Sakurai, Masami Hayashi

Keywords

Post-genomic research, Sugar chain, Neuro-muscular function, Aging model mouse

Major Research Titles

1) Dementia-associated changes of glycoproteins
2) Research on a mouse model resembling human aging
3) Glycobiology on neuro-muscular functions

 We are mainly focusing on post-genomic research in aging. We try to elucidate the mechanisms of normal aging and geriatric diseases by analyses of the processes of posttranslational modifications, specially focusing on glycosylation.

1) Dementia-associated change of glycoproteins
 Glycosylation is a common type of posttranslational modification of proteins that can affect its function in many ways. We are focusing on changes of the glycosylation state of brain glycoproteins during dementia.

2) Research on a mouse model resembling human aging
 Using by an animal model, klotho mouse, that prematurely shows phenotypes resembling human aging, we find that the abnormal activation of calpain. We try to characterize these detailed processes.

3) Glycobiology on neuro-muscular functions
 We identify that two congenital muscular dystrophies, muscle-eye-brain disease and Walker-Warburg syndrome, are caused by defects in glycosyltransferases. We try to identify the molecular mechanism of these diseases, and to address between the changes of glycans and age-associated deterioration of muscle.

Based on above strategies, we will open a new venue for the post-genomic research in gerontology and geriatrics.

References

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Tokyo Metropolitan Institute of Gerontology
2012/08/22
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