Tokyo Metropolitan Institute of Gerontology

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Proteome Research

Toda, T., Sugimoto, M., Omori, A., Matsuzaki, T., Furuichi, Y. and Kimura, N.: Proteomic analysis of Epstein-Barr virus-transformed human B-lymphoblastoid cell lines before and after immortalization. Electrophoresis, 21(9), 1814-1822, 2000

Toda, T.: Proteome and Proteomics for the research on protein alterations in aging. New York Acad. Sci., 928, 71-78, 2001

Nishigaki, R., Shinohara T., Toda, T., Omori, A., Ichinose, S., Itoh, M., Shirayoshi, Y.,Kurimasa, A., and Oshimura, M.: An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. Biochem. Biophys. Res. Comm. 295(1), 112-118, 2002

Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H, Watanabe T, Ohama E, Tahimic CG, Kurimasa A, Oshimura M.: Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem Biophys Res Commun. 309(3), 558-566, 2003

Kamino H, Hiratsuka M, Toda T, Nishigaki R, Osaki M, Ito H, Inoue T, Oshimura M.: Searching for genes involved in arteriosclerosis: proteomic analysis of cultured human umbilical vein endothelial cells undergoing replicative senescence. Cell Struct Funct. 28(6), 495-503, 2003

Morisawa H, Toda T.: Collaborative proteomics framework with XML databases and an integrated XML viewer for 2DPAGE. J Electrophoresis, 49(1), 35-38, 2005.

Miura Y, Kano M, Abe K, Urano S, Suzuki S, Toda T.: Age-dependent variations of cell response to oxidative stress: proteomic approach to protein expression and phosphorylation. Electrophoresis. 26(14), 2786-2796, 2005.

Sato Y, Yamanaka H, Toda T, Shinohara Y, Endo T.: Comparison of hippocampal synaptosome proteins in young-adult and aged rats. Neurosci Lett. 382(1-2), 22-26, 2005..

Feng D, Imasawa T, Nagano T, Kikkawa M, Takayanagi K, Ohsawa T, Akiyama K, Ishigami A, Toda T, Mitarai T, Machida T, Maruyama N.: Citrullination preferentially proceeds in glomerular Bowman's capsule and increases in obstructive nephropathy. Kidney Int. 68(1), 84-95, 2005.

10.

Nakamura M, Sakurai Y, Takeda Y, Toda T.: Comparative proteomics of flotillin-rich Triton X-100-insoluble lipid raft fractions of mitochondria and synaptosome from mouse brain. J Electrophoresis. 49(4), 77-83, 2005.

11.

Tahimic CG, Tomimatsu N, Nishigaki R, Fukuhara A, Toda T, Kaibuchi K, Shiota G, Oshimura M, Kurimasa A.: Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells. Biochem Biophys Res Commun. 340(4),1244-1250, 2006.

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Nakamura M, Yamada M, Ohsawa T, Morisawa H, Nishine T, Nishimura O, Toda T.: Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress. Biochem Biophys Acta 1763(9), 977-989, 2006.

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Morisawa H, Hirota M, Toda T.: Development of an open source laboratory information management system for 2-D gel electrophoresis-based proteomics workflow. BMC Bioinformatics 7:430-440, 2006.

14.

Sato Y, Suzuki Y, Ito E, Shimazaki S, Ishida M, Yamamoto T, Yamamoto H, Toda T, Suzuki M, Suzuki A, Endo T.: Identification and characterization of an increased glycoprotein in aging: age-associated translocation of cathepsin D. Mech Ageing Dev. 127(10), 771-778, 2006.

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Hashimoto R, Toda T, Tsutsumi H, Ohta M, Mori M: Abnormal N-Glycosylation of the Immunoglobulin G κ Chain in a Multiple Myeloma Patient with Crystalglobulinemia. Int. J. Hematol., 85(3), 203-206, 2007.

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Miura Y, Kano M, Yamada M, Nishine T, Urano S, Suzuki S, Endo T, Toda T.: Proteomic Study on X-irradiation-responsive Proteins and Ageing: Search for Responsible Proteins for Radiation Adaptive Response. J Biochem (Tokyo), 142(2), 145-155, 2007.

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Toda T, Nakamura M, Morisawa H, Hirota M.: Proteomic identification of oxidative-stress-reporting biomarkers differentially secreted from human neuroblastoma SH-SY5Y cells. J Electrophoresis, 51(3/4), 21-26, 2007.

18.

Kurosaki H, Kazuki Y, Hiratsuka M, Inoue T, Matsui Y, Wang, CC, Kanatsu-Shinohara M, Shinohara T, Toda T., Oshimura M.: A comparison study in the proteomic signatures of multipotent germline stem cells, embryonic stem cells, and germline stem cells. Biochem Biophys Res Comm, 353, 259-267, 2007.

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Akama K, Tatsuno R, Otsu M, Horikoshi T, Nakamura M, Toda T, Inoue N.: Proteomic identification of differentially expressed genes in ouse neural stem cells and neurons differentiated from embryonic stem cells in vitro. Biochim. Biophys. Acta, 1784, 773-782, 2008.

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Toda T, Nakamura M, Yamada M, Nishine T, Torii T, Ikenaka K, Hashimoto R, Mori M.: Glycoproteomic analysis of abnormal N-glycosylation on the kappa chain of cryocrystalglobulin in a patient of multiple myeloma. J Electroph, 53(1), 1-6, 2009.

21.

Nakamura M, Morisawa H, Imajoh-Ohmi S, Takamura C, Fukuda H, Toda T.: Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: An increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress. Exp Gerontol 44(6-7), 375-382, 2009.

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Tadokoro T, Ikekita M, Toda T, Ito H, Sato T, Nakatani R, Hamaguchi Y, Furukawa K.: Involvement of Galectin-3 with Vacular Cell Adhesion Molecule-1 in Growth Regulation of Mouse BALB/3T3 cells. J Biol Chem 284(51), 35556-35563, 2009.

23.

Akama K, Horikoshi T, Sugiyama A, Nakahata S, Akitsu A, Niwa N, Intoh A, Kakui Y, Sugaya M, Takei K, Imaizumi N, Sato T, Matsumoto R, Iwahashi H, Kashiwabara SI, Baba T, Nakamura M, Toda T.: Protein disulfide isomerase-P5, down-regulated in the final stage of boar epididymal sperm maturation, catalyzes disulfide formation to inhibit protein function in oxidative refolding of reduced denatured lysozyme. Biochim Biophys Acta 1804(6), 1272-1284, 2010.

24.

Toda T, Nakamura M, Morisawa H, Hirota M, Nishigaki R, Yoshimi Y.: Proteomic approaches to oxidative protein modifications implicated in the mechanism of aging. Geriatr Gerontol Int, 10 (Suppl.1), S25-S31, 2010.