Molecular Gerontology

1.

  Nakajima, M., and Shirasawa, T. (2004). Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro. Neuroscience 125, 563-568.

2.

  Shin, R. M., Masuda, M., Miura, M., Sano, H., Shirasawa, T., Song, W. J., Kobayashi, K., and Aosaki, T. (2003). Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J Neurosci 23, 11662-11672.

3.

  Shirasawa, T. (2003). [Longevity and genes]. Nippon Ronen Igakkai Zasshi 40, 596-598

4.

  Izumizaki, M., Tamaki, M., Suzuki, Y., Iwase, M., Shirasawa, T., Kimura, H., and Homma, I. (2003). The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Presbyterian hemoglobinopathy. Am J Physiol Regul Integr Comp Physiol 285, R747-753.

5.

  Nakajima, M., Yuasa, S., Ueno, M., Takakura, N., Koseki, H., andShirasawa, T. (2003). Abnormal blood vessel development in mice lackingpresenilin-1. Mech Dev 120, 657-667.

6.

  Murakami, K., Irie, K., Morimoto, A., Ohigashi, H., Shindo, M.,Nagao, M., Shimizu, T., and Shirasawa, T. (2003). Neurotoxicity andphysicochemical properties of Abeta mutant peptides from cerebral amyloidangiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease. J Biol Chem 278, 46179-46187.

7.

  Hidenori Morio, Yoko Honda, Hidenao Yoyoda, Mitsunari Nakajima,Hisashi Kurosawa, and Takuji Shirasawa (2002) EXT gene family member rib-2is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans. Biochem Biophys Res Commun, 301, 317-323

8.

  Takamune Takahashi, Keiko Takahashi, Patricia St. John, Paul A..Fleming, Takuya Tomemori, Toshio Watanabe, Dale R. Abrahamson, ChristopherJ. Drake, Takuji Shirasawa, and Thomas O. Daniel (2002) A Mutant ReceptorTyrosine Phosphatase CD148 Causes Defects in Vascular Development. Mol.Cell. Biol. 23, 1817-1831

9.

  Youngah Shin, Hyun Soon Cho, Hiroyuki Fukumoto, Takahiko Shimizu,Takuji Shirasawa, Steven M. Greenberg, and G. William Rebeck (2002) Abspecies, including IsoAsp 23 Ab, in Iowa-type familial cerebral amyloidangiopathy. Acta Neuropathologica 105, 252-258

10.

  Shirasawa, T., Izumizaki, M., Suzuki, Y. I., Ishihara, A., Shimizu,T., Tamaki, M., Huang, F., Koizumi, K. I., Iwase, M., Sakai, H., Tsuchida,E., Ueshima, K., Inoue, H., Koseki, H., Senda, T., Kuriyama, T., and Homma,I. (2002). Oxygen affinity of hemoglobin regulates O2 consumption,metabolism, and physical activity. J Biol Chem 278, 5035-5043.

11.

  Shimizu, T., Fukuda, H., Murayama, S., Izumiyama, N., and Shirasawa,T. (2002). Isoaspartate formation at position 23 of amyloid beta peptideenhanced fibril formation and deposited onto senile plaques and vascularamyloids in Alzheimer's disease. J Neurosci Res 70, 451-461.

12.

  Yuasa, S., Nakajima, M., Aizawa, H., Sahara, N., Koizumi, K., Sakai,T., Usami, M., Kobayashi, S., Kuroyanagi, H., Mori, H., Koseki, H., andShirasawa, T. (2002). Impaired cell cycle control of neuronal precursorcells in the neocortical primordium of presenilin-1-deficient mice. JNeurosci Res 70, 501-513.

13.

  Ishigami, A., Fujita, T., Handa, S., Shirasawa, T., Koseki, H.,Kitamura, T., Enomoto, N., Sato, N., Shimosawa, T., and Maruyama, N. (2002).Senescence Marker Protein-30 Knockout Mouse Liver Is Highly Susceptible to Tumor Necrosis Factor-alpha- and Fas-Mediated Apoptosis. Am J Pathol 161, 1273-1281.

14.

  Morimoto, A., Irie, K., Murakami, K., Ohigashi, H., Shindo, M.,Nagao, M., Shimizu, T., and Shirasawa, T. (2002). Aggregation andneurotoxicity of mutant amyloid beta (Abeta) peptides with prolinereplacement: importance of turn formation at positions 22 and 23. BiochemBiophys Res Commun 295, 306-311.

15.

  Ikegami, T., Suzuki, Y., Shimizu, T., Isono, K., Koseki, H., andShirasawa, T. (2002). Model mice for tissue-specific deletion of themanganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun 296, 729.

16.

  Suzuki, Y., Shimizu, T., Sakai, H., Tamaki, M., Koizumi, K.,Kuriyama, T., Tsuchida, E., Koseki, H., and Shirasawa, T. (2002). Model mice for Presbyterian hemoglobinopathy (Asn(beta108)-->Lys) confer hemolytic anemia with altered oxygen affinity and instability of Hb. Biochem Biophys Res Commun 295, 869-876.

17.

  Ogawara, M., Takahashi, M., Shimizu, T., Nakajima, M., Setoguchi, Y.,and Shirasawa, T. (2002). Adenoviral expression of protein-L-isoaspartylmethyltransferase (PIMT) partially attenuates the biochemical changes inPIMT-deficient mice. J Neurosci Res 69, 353-361.

18.

  Shimizu, T., Ikegami, T., Ogawara, M., Suzuki, Y., Takahashi, M.,Morio, H., and Shirasawa, T. (2002). Transgenic expression of theprotein-L-isoaspartyl methyltransferase (PIMT) gene in the brain rescuesmice from the fatal epilepsy of PIMT deficiency. J Neurosci Res 69, 341-352
 

19.

  Murakami, K., Irie, K., Morimoto, A., Ohigashi, H., Shindo, M.,Nagao, M., Shimizu, T., and Shirasawa, T. (2002). Synthesis, aggregation,neurotoxicity, and secondary structure of various Abeta1-42 mutants offamilial Alzheimer's disease at positions 21-23. Biochem Biophys Res Commun
 

20.

  Morimoto, K., Shimizu, T., Furukawa, K., Morio, H., Kurosawa, H., andShirasawa, T. (2002). Transgenic expression of the EXT2 gene in developingchondrocytes enhances the synthesis of heparan sulfate and bone formation in mice. Biochem Biophys Res Commun 292, 999-1009.
 

21.

  Smith, C. D., Carson, M., Friedman, A. M., Skinner, M. M., Delucas,L., Chantalat, L., Weise, L., Shirasawa, T., and Chattopadhyay, D. (2002).Crystal structure of human L-isoaspartyl-O-methyl-transferase withS-adenosyl homocysteine at 1.6-A resolution and modeling of anisoaspartyl-containing peptide at the active site. Protein Sci 11, 625-635.