Organ Disorder and Aging Research Group

Naoki Maruyama, M.D., Ph.D.

Akihito Ishigami, Ph.D., Sachiho Kubo, Setsuko Handa, Masashi Kuramoto, Ph.D.(Japan Foundation for Aging and Health), Emilio Antonio Jeckel-Neto, Ph.D. (Japan Foundation for Aging and Health)

Visiting Scientists :
Akisa Tsunemi, M.D.(Tokyo Medical and Dental University, School of Medicine)

geriatric diseases, Senescence Marker Protein-30 (SMP30), peptidylarginine
deiminase (PAD), adrenomedullin, Muscle specific kinase (MuSK), agrin

Our physical condition gradually deteriorates with aging. There are various molecular events in this deterioration. The aim of our research group is the elucidation of the mechanisms of geriatric diseases and the application of our findings to therapy or prevention of such diseases. To achieve our aim we are analysing the process of disease onset via molecular abnormality by using animal models and/or human cultured cell line. Our research projects are characterized by the molecule and phenomena discovered by ourselves.

1) Senescence marker protein- 30 (SMP30) and age-associated organ disorder
2) Peptidylarginine deiminase (PAD) and age-associated organ disorder
3) Adrenomedullin and age-associated organ disorder
4) Molecular biology of neuromuscular junction
5) Age-associated nephropathy