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Research on Healthy Aging and Community Health

Members

Theme Leader :
Akihiko Kitamura, M.D., Ph.D.
Vice-Chief Researcher :
Yukitoshi Aoyagi, Ph.D.
Researcher :
Mariko Nishi, Ph.D., Satoshi Seino, Ph.D., Yuri Yokoyama, Ph.D.,R.D., Yu Nofuji, Ph.D.
Associate Researcher :
Hidenori Amano, M.H.S.
Adjunct Researcher :
Miki Narita, M.Med.Sci., M.Sc., R.D., Sung-Jin Park, M.Sc., Tomoko Ikeuchi, Ph.D., Yui Tomine, Ph.D. Takumi Abe, Ph.D., OT., Mari Yamashita, Ph.D., Sunyoung Cho, Ph.D., Ayako Oura, Ph.D., Shin Takahashi, M.Sc.

Keywords

Healthy aging, Functional ability, Intrinsic capacity, Trajectory patterns, Long-term care service, Community system, Social environment, Social participation, Social contribution, Epidemiological study

Major Research Titles

  1. 1.Trajectory patterns of functional ability and intrinsic capacity and associated factors
  2. 2.Development of a community-based comprehensive system to promote healthy aging
  3. 3.Establishing a guideline of physical activity for community-dwelling older adults

Profile

Healthy aging reflects that people live independently while maintaining physical, psychological, and social functions. To achieve healthy aging, we consider two necessary points: 1) maintaining intrinsic capacity (physical and psychological functions) and 2) creating supportive social and physical environments to facilitate healthy lifestyle and access to long-term care services in order to maintain functional ability of individuals with even lower levels of intrinsic capacity. Our research establishes evidence of individuals approach and social system for achieving healthy aging, which enables people to live in their communities with satisfaction.

1.Trajectory patterns of functional ability and intrinsic capacity and associated factors
Our longitudinal data have revealed that physical and cognitive function among older adults can be classified into several specific patterns. For example, approximately half of older adults were classified as having higher cognitive function, whereas 5% of them had lower cognition at age 65 years and showed rapid cognitive decline after age 75 years.
We will focus on specific-aging patterns of functional ability and intrinsic capacity and examine the associations between trajectory patters and life style and/or socioeconomic status. We believe that our study will contribute to strategy development to improve health and longevity outcomes.

2.Development of a community-based comprehensive system to promote healthy aging
In order to achieve healthy aging, promoting a) physical exercise, b) diverse nutrition intake including protein, and c) active social engagement and contributions and social participation at both individual and community levels are important, in addition to managing lifestyle diseases. We have proposed models for frailty prevention in hilly and mountainous suburban areas through a 3-year collaborative research project called “Development of a Community-based Comprehensive System for Prevention of Frailty in Late Life.”
On the basis of past studies, we have launched the Ota Genki Senior Project to construct a model for frailty prevention in the greater Tokyo area. We will examine the effectiveness of these social mechanisms and expand them to other communities.

3.Establishing a guideline of physical activity for community-dwelling older adults
In our ongoing Nakanojo Study, we have obtained the long-term data on physical activity patterns (daily, monthly and seasonal) in a large-scale sample of community-dwelling older persons using pedometers/accelerators. This study aims to establish a guideline of physical activity for promoting health for older adults.

References

  1. 1. Taniguchi Y, Kitamura A, Nofuji Y, Ishizaki T, Seino S, Yokoyama Y, Shinozaki T, Murayama H, Mitsutake S, Amano H, Nishi M, Matsuyama Y, Fujiwara Y, Shinkai S. Association of Trajectories of Higher-Level Functional Capacity with Mortality and Medical and Long-Term Care Costs Among Community-Dwelling Older Japanese. J Gerontol A Biol Sci Med Sci. in press.
  2. 2. Taniguchi Y, Kitamura A, Shinozaki T, Seino S, Yokoyama Y, Narita M, Amano H, Matsuyama Y, Fujiwara Y, Shinkai S. Trajectories of Arterial Stiffness and All-Cause Mortality Among Community-Dwelling Older Japanese. Geriatr Gerontol Int, in press.
  3. 3. Taniguchi Y, Kitamura A, Seino S, Murayama H, Amano H, Nofuji Y, Nishi M, Yokoyama Y, Shinozaki T, Yokota I, Matsuyama Y, Fujiwara Y, Shinkai S: Gait Performance Trajectories and Incident Disabling Dementia Among Community-Dwelling Older Japanese. J Am Med Dir Assoc. 2017;18(2):192.e13-192.e20.
  4. 4. Taniguchi Y, Kitamura A, Murayama H, Amano H, Shinozaki T, Yokota I, Seino S, Nofuji Y, Nishi M, Yokoyama Y, Matsuyama Y, Fujiwara Y, Shinkai S: Mini-Mental State Examination Score Trajectories and Incident Disabling Dementia Among Community-Dwelling Older Japanese. Geriatr Gerontol Int. 2017; 17(11):1928-1935,.
  5. 5. Seino S, Kitamura A, Tomine Y, Tanaka I, Nishi M, Nonaka K, Nofuji Y, Narita M, Taniguchi Y, Yokoyama Y, Amano H, Ikeuchi T, Fujiwara Y, Shinkai S: A community-wide intervention trial for preventing and reducing frailty among older adults living in metropolitan areas: Design and baseline survey for a study integrating participatory action research with cluster trial. J Epidemiol, in press.
  6. 6. Seino S, Nishi M, Murayama H, Narita M, Yokoyama Y, Nofuji Y, Taniguchi Y, Amano H, Kitamura A, Shinkai S: Effects of a multifactorial intervention comprising resistance exercise, nutritional, and psychosocial programs of frailty and functional health in community-dwelling older adults: a randomized, controlled, crossover trial. Geriatr Gerontol Int. 2017;17(11):2034-2045.
  7. 7. Seino S, Sumi K, Narita M, Yokoyama Y, Ashida K, Kitamura A, Shinkai S. Effects of low-dose dairy protein plus micronutrient supplementation during resistance exercise on muscle mass and physical performance in older adults: A randomized, controlled trial. J Nutr Health Aging, 2018;22(1):59-67..
  8. 8. Murayama H, Shinkai S, Nishi M, Taniguchi Y, Amano H, Seino S, Yokoyama Y, Yoshida H, Fujiwara Y, Ito H: Albumin, hemoglobin, and the trajectory of cognitive function in community-dwelling older Japanese: a 13-year longitudinal study. Journal of Prevention of Alzheimer's Disease. http://dx.doi.org/10.14283/jpad.2016.113
  9. 9. Aoyagi Y, Park S, Matsubara S, Honda Y, Amamoto R, Kushiro A, Miyazaki K, Shephard R.J: Habitual intake of fermented milk products containing Lactobacillus casei strain Shirota and a reduced risk of hypertension in older people. Beneficial Microbes. 2017;8(1):23-29.
  10. 10. Shephard R.J, Park H, Park S, Aoyagi Y : Objectively measured physical activity and calcaneal bone health in older Japanese adults: dose/response relationships in longitudinal data from the Nakanojo Study. Journal of the American Geriatrics Society. 2017;65(4):800-807.
  11. 11. Yokoyama Y, Nishi M, Murayama H, Amano H, Taniguchi Y, Nofuji Y, Narita M, Matsuo E, Seino S, Kawano Y, Shinkai S : Dietary variety and decline in lean mass and physical performance in community-dwelling older Japanese: A 4-year follow-up study. J Nutr Health Aging. 2017;21(1):11-16.
  12. 12. Murayama H, Shinkai S, Nishi M, Taniguchi Y, Amano H, Seino S, Yokoyama Y, Yoshida H, Fujiwara Y, Ito H: Albumin, hemoglobin, and the trajectory of cognitive function in community-dwelling older Japanese: a 13-year longitudinal study. Journal of Prevention of Alzheimer's Disease. http://dx.doi.org/10.14283/jpad.2016.113
  13. 13. Taniguchi Y, Fujiwara Y, Murayama H, Yokota I, Matsuo E, Seino S, Nofuji Y, Nishi M, Matsuyama Y, Shinkai S: Prospective Study of Trajectories of Physical Performance and Mortality Among Community-Dwelling Older Japanese. J Gerontol A Biol Sci Med Sci. 2016;71(11):1492-1499.
  14. 14. Yokoyama Y, Nishi M, Murayama H, Amano H, Taniguchi Y, Nofuji Y, Narita M, Matsuo E, Seino S, Kawano Y, Shinkai S : Association of dietary variety with body composition and physical function in community-dwelling elderly Japanese. J Nutr Health Aging. 2016;20(7):691-696.
  15. 15. Shinkai S, Yoshida H, Taniguchi Y, Murayama H, Nishi M, Amano H, Nofuji Y, Seino S, Fujiwara Y : Public health approach to preventing frailty in the community and its effect on healthy aging in Japan. Geriatrics Gerontology International, 2016 Mar;16 Suppl 1:87-97. doi: 10.1111/ggi.12726.
  16. 16. Nofuji Y, Shinkai S, Taniguchi Y, Amano H, Nishi M, Murayama H, Fujiwara Y, Suzuki T : Associations of Walking Speed, Grip Strength, and Standing Balance with Total and Cause-Specific Mortality in a General Population of older Japanese. Journal of American Directors Association, 2016, 17(2), 184.e1-7.
  17. 17. Taniguchi Y, Fujiwara Y, Nishi M, Murayama H, Nofuji Y, Seino S, Shinkai S: Prospective study of arterial stiffness and subsequent cognitive decline among community-dwelling older Japanese. Journal of Epidemiology, 2015, 25(9), 592-599
  18. 18. Murayama H, Nishi M, Nofuji Y, Matsuo E, Taniguchi Y, Amano H, Yokoyama Y, Fujiwara Y, Shinkai S. Longitudinal association between neighborhood cohesion and depressive mood in old age: A Japanese prospective study. Health & Place, 2015, 34, 270-278.
  19. 19. Murayama H, Liang J, Bennett JM, Shaw BA, Botoseneanu A, Kobayashi E, Fukaya T, Shinkai S : Trajectories of body mass index and their associations with mortality among older Japanese: Do they differ from Western populations? American Journal of Epidemiology, 2015, 182(7), 597-605.
  20. 20. Seino S, Shinkai S, Iijima K, Obuchi S, Fujiwara Y, Yoshida H, Kawai H, Nishi M, Murayama H, Taniguchi Y, Amano H, Takahashi R : Reference values and age differences in body composition of community-dwelling older Japanese men and women: A pooled analysis of four cohort studies. PLoS ONE, 2015, 10(7), e0131975.
  21. 21. Ayabe M, Park S, Shephard R.J, Aoyagi Y : Associations of activity monitor output and an estimate of aerobic fitness with pulse wave velocities: the Nakanojo Study. Journal of Physical Activity and Health, 2015, 12, 139-144.
  22. 22. Murayama H, Bennett JM, Shaw BA, Liang J, Krause N, Kobayashi E, Fukaya T, Shinkai S : Does social support buffer the effect of financial strain on the trajectory of smoking in older Japanese? A 19-year longitudinal study. Journal of Gerontology: Psychological Sciences & Social Sciences, 2015, 70(3), 367-376.
  23. 23. Murayama H, Liang J, Bennett JM, Shaw BA, Botoseneanu A, Kobayashi E, Fukaya T, Shinkai S : Socioeconomic status and the trajectory of body mass index among older Japanese: a nationwide cohort study of 1987-2006. Journal of Gerontology: Psychological Sciences and Social Sciences, 2015, 71(2), 378-388.
  24. 24. Murayama H, Nofuji Y, Matsuo E, Nishi M, Taniguchi Y, Fujiwara Y, Shinkai S : Are neighborhood bonding and bridging social capital protective against depressive mood in old age? A multilevel analysis in Japan. Social Science and Medicine, 2015, 124, 171-179.