Glycans are biosynthesized without a template unlike proteins and nucleic acids. They have characteristics that reflect the physiological state of cells, and are important for understanding aging process. More than half of the proteins produced in our body are post-translationally modified with glycans. Currently, I am performing to clarify the potential of glycans as aging markers, and to clarify the relationship between glycans and aging-associated diseases such as Alzheimer's disease and sarcopenia, etc. The research concept is shown below.
References
1. Miura, Y., Tsumoto, H., Masui, Y., Inagaki, H., Ogawa, M., Ideno, Y., Kawakami, K., Umezawa, K., Kabayama, M., Akagi, Y., Akasaka, H., Yamamoto, K., Rakugi, H., Ishizaki, T., Arai, Y., Ikebe, K., Kamide, Gondo, Y., and Endo, T. A characteristic N-glycopeptide signature associated with diabetic cognitive impairment identified in a longitudinal cohort study. Biochim. Biophys. Acta, 1867, 130316, 2023.
2. Endo, T. Glycans and muscular dystrophy. in Encyclopedia of Cell Biology, Second Edition, (R. Bradshaw., P. Stahl, G. Hart, eds) vol. 4, pp. 396-403, Oxford: Elsevier. 2023.
3. Tokuoka, H., Imae, R., Nakashima, H., Manya, H., Masuda, C., Hoshino, S., Kobayashi, K., D.J. Lefeber, Matsumoto, R., Okada, T., Endo, T., Kanagawa, M., and Toda, T. CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model. Nat. Commun., 13, 1847, 2022.
4. Tamura, J., Tamura, T., Hoshino, S., Imae, R., Kato, R., M, Yokono., Nagase, M., Ohno, S., Manabe, N., Yamaguchi, Y., Manya, H., and Endo, T. Chemical and chemo-enzymatic syntheses of glycans containing ribitol phosphate scaffolding of matriglycan. ACS Chem. Biol., 17, 1513, 2022.
5. Endo, T. Decoding of α-dystroglycan glycosylation and muscular dystrophy. in GLYCOME: THE HIDDEN CODE IN BIOLOGY. D K Banerjee. (Ed.) Nova Publisher, pp. 141-159, 2021.
6. Akimoto, Y., Miura, Y., Endo, T., and Gerald W. Hart. O-GlcNAcylation and Diabetes. in Comprehensive Glycoscience, 2nd Edition, (J. Barchi, Jr., S. Vidal, S. Williams, R. Narain, N. Taniguchi, eds) Elsevier, pp. 133-148, 2021.
7. Iijima, K., Arai, H., Akishita, M., Endo, T., Ogasawara, K., Kashihara, N., Hayashi, Y.K., Yumura, K., Yokode, M., and Ouchi, Y. Proposal from the Science Council of Japan (Term 24) Toward the development of a vibrant, super-aged society: The future of medicine and society in Japan. Geriatr. Gerontol. Int., 21, 601-613, 2021.
8. Furukawa, J., Hanamatsu, H., Nishikaze, T., Manya, H., Miura, N., Yagi, H., Yokota, I., Akasaka-Manya, K., Endo, T., Kanagawa, M., Iwasaki, N., and Tanaka, K. Lactone-driven ester-to-amide derivatization for sialic acid linkage-specific alkylamidation (LEAD-SALSA). Anal. Chem., 92, 14383-14392, 2020.
9. Kuwabara, N., Imae, R., Manya, H., Tanaka, T., Mizuno, M., Tsumoto, H., Kanagawa, M., Kobayashi, K., Toda, T., Senda, T., Endo, T., and Kato, R. Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy. Nat. Commun., 11, 303, 2020.
10. Glycoscience: Basic Science to Applications: Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG)Editors: Taniguchi, N., Endo, T., Hirabayashi, J., Nishihara, S., Kadomatsu, K., Akiyoshi, K., Aoki-Kinoshita, K.F. (Eds.) Springer, 405 pages, 2019.
