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Research Team for Functional Biogerontology

Team Leader

Akihito Ishigami, Ph.D.


The final goal of our studies is to provide opportunities for elderly citizens to enjoy healthy and successful aging by regulating the various aging processes on the basis of molecular mechanisms underlying the functional changes with age. Toward this goal, our research team is investigating the fundamental means that improve the quality of life of the elderly by integration of multiple approaches from different disciplines.
The research group of Genomics for Longevity and Health is engaged in studies on the roles of sex steroid hormones and vitamins which are involved in age-related diseases such as cancers and conditions composing locomotive syndrome.
The group of Molecular Regulation of Aging is aiming at prevention of aging process by administration of antioxidants, e.g., ascorbic acid. This group has identified the casual relationship between vitamin C deficiency and chronic obstructive pulmonary disease (COPD).
The group of Biological Process of Aging investigates the effect of molecular hydrogen, a potent antioxidant and anti-inflammatory agent, has multiple potentials to prevent various pathological processes and aging.

Major Research Titles